Pld5 MGI Mouse Gene Detail - MGI:2442056 - phospholipase D family member 5

Symbol

Pld5
Name

phospholipase D family member 5
Synonyms

B230365F16Rik

Feature Type

protein coding gene
IDs

MGI:2442056
NCBI Gene: 319455
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:175789872-176102878 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.90 cM
Mapping Data

1 experiment

SNPs within 2kb

10741 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442056	protein coding gene	Chr1:175789867-176109078 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016843	protein coding gene	Chr1:182061612-182410043 (-)
A/J	MGP_AJ_G0016822	protein coding gene	Chr1:174732707-175061428 (-)
AKR/J	MGP_AKRJ_G0016788	protein coding gene	Chr1:179967111-180303184 (-)
BALB/cJ	MGP_BALBcJ_G0016780	protein coding gene	Chr1:175266078-175590518 (-)
C3H/HeJ	MGP_C3HHeJ_G0016605	protein coding gene	Chr1:180558010-180891866 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017245	protein coding gene	Chr1:188074788-188419583 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014950	protein coding gene	Chr1:166050055-166373974 (-)
CAST/EiJ	MGP_CASTEiJ_G0016186	protein coding gene	Chr1:179933558-180263970 (-)
CBA/J	MGP_CBAJ_G0016579	protein coding gene	Chr1:194909158-195272819 (-)
DBA/2J	MGP_DBA2J_G0016684	protein coding gene	Chr1:173588967-173911215 (-)
FVB/NJ	MGP_FVBNJ_G0016681	protein coding gene	Chr1:171707845-172027255 (-)
LP/J	MGP_LPJ_G0016760	protein coding gene	Chr1:183255000-183599740 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016713	protein coding gene	Chr1:202167965-202518887 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017280	protein coding gene	Chr1:179717266-180055588 (-)
PWK/PhJ	MGP_PWKPhJ_G0015973	protein coding gene	Chr1:172679950-173003784 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015750	protein coding gene	Chr1:178756670-179100539 (-)
WSB/EiJ	MGP_WSBEiJ_G0016248	protein coding gene	Chr1:179923391-180253810 (-)

Human Ortholog

PLD5, phospholipase D family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLD5, phospholipase D family member 5
Synonyms

PLDC
Links

HGNC:26879

NCBI Gene ID: 200150

neXtProt AC: NX_Q8N7P1

UniProt: Q8N7P1
Chr Location

1q43; chr1:242082986-242530546 (-) GRCh38

MGI Vertebrate Homology

Pld5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLD5
Gene Tree

Pld5

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Gene trapped

1
Targeted

2
Genomic Mutations

2 involving Pld5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

No abnormal phenotype was observed in a high-throughput screen, nor in a pathology assessment.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

74
RefSeq

30
UniProt

5
CCDS

CCDS15552.1, CCDS56660.1

Ensembl

ENSMUSG00000055214 (Evidence)
NCBI Gene

319455

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055214	Ensembl Gene Model \| MGI Sequence Detail	313007	C57BL/6J	± kb
transcript	ENSMUST00000065967	Ensembl \| MGI Sequence Detail	3557	Not Applicable
polypeptide	ENSMUSP00000069326	Ensembl \| MGI Sequence Detail	536	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012847 inactive phospholipase D5

(term hierarchy)
InterPro Domains

IPR050874 Diverse function phospholipase D-related protein

IPR001736 Phospholipase D/Transphosphatidylase

IPR032803 PLD-like domain
GlyGen

Q3UNN8 7 sites, 6 N-linked glycans (6 sites)

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All nucleic 10

cDNA 10

Microarray probesets 1

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pld5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15411	Chr1:176102849-176102874 (-)	16 bp
Tssr15410	Chr1:176041607-176041613 (-)	61,268 bp
Tssr15409	Chr1:176041581-176041590 (-)	61,292 bp
Tssr15408	Chr1:176041540-176041543 (-)	61,336 bp
Tssr15407	Chr1:176041524-176041533 (-)	61,349 bp
Tssr15406	Chr1:176041500-176041509 (-)	61,373 bp
Tssr15405	Chr1:176041335-176041345 (-)	61,538 bp
Tssr15404	Chr1:176041306-176041313 (-)	61,568 bp
Tssr15403	Chr1:176041270-176041284 (-)	61,601 bp
Tssr15402	Chr1:176041239-176041250 (-)	61,633 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24