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Ppm1h Gene Detail
Summary
  • Symbol
    Ppm1h
  • Name
    protein phosphatase 1H (PP2C domain containing)
  • Synonyms
    A430075L18Rik, ARHCL1, C030002B11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442087
    NCBI Gene: 319468
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:122514667-122781700 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 70.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8986 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442087
 protein coding gene Chr10:122512720-122781700 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017790
 protein coding gene Chr10:125997144-126283718 (+)
A/J MGP_AJ_G0017765
 protein coding gene Chr10:120961320-121231266 (+)
AKR/J MGP_AKRJ_G0017728
 protein coding gene Chr10:124596348-124864496 (+)
BALB/cJ MGP_BALBcJ_G0017729
 protein coding gene Chr10:121386344-121657815 (+)
C3H/HeJ MGP_C3HHeJ_G0017553
 protein coding gene Chr10:124776355-125060435 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018184
 protein coding gene Chr10:130256968-130546043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015864
 protein coding gene Chr10:115228700-115491174 (+)
CAST/EiJ MGP_CASTEiJ_G0017113
 protein coding gene Chr10:125178727-125465214 (+)
CBA/J MGP_CBAJ_G0017522
 protein coding gene Chr10:135582226-135886728 (+)
DBA/2J MGP_DBA2J_G0017628
 protein coding gene Chr10:120100654-120370027 (+)
FVB/NJ MGP_FVBNJ_G0017623
 protein coding gene Chr10:119084829-119347606 (+)
LP/J MGP_LPJ_G0017702
 protein coding gene Chr10:126537216-126821704 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017651
 protein coding gene Chr10:138088166-138373192 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018224
 protein coding gene Chr10:124628534-124913724 (+)
PWK/PhJ MGP_PWKPhJ_G0016898
 protein coding gene Chr10:120217162-120488450 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016690
 protein coding gene Chr10:123536194-123815276 (+)
WSB/EiJ MGP_WSBEiJ_G0017174
 protein coding gene Chr10:124817778-125090549 (+)



Homology
more
  • Human Ortholog
    PPM1H, protein phosphatase, Mg2+/Mn2+ dependent 1H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1H, protein phosphatase, Mg2+/Mn2+ dependent 1H
  • Synonyms
    ARHCL1, NERPP-2C, URCC2
  • Links
    NCBI Gene ID: 57460
    neXtProt AC: NX_Q9ULR3
    UniProt: Q9ULR3

  • Chr Location
    12q14.1-q14.2; chr12:62643994-62935150 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous or homozygous for a null allele exhibit loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    9
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034613 Ensembl Gene Model | MGI Sequence Detail 267034 C57BL/6J ±  kb
    transcript ENSMUST00000067918 Ensembl | MGI Sequence Detail 6369 Not Applicable  
    polypeptide ENSMUSP00000066561 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925790
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory