Ppm1k MGI Mouse Gene Detail - MGI:2442111 - protein phosphatase 1K (PP2C domain containing)

Symbol

Ppm1k
Name

protein phosphatase 1K (PP2C domain containing)
Synonyms

2900063A19Rik, A930026L03Rik, PP2Cm

Feature Type

protein coding gene
IDs

MGI:2442111
NCBI Gene: 243382
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:57483487-57512453 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 27.82 cM
Mapping Data

1 experiment

SNPs within 2kb

794 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442111	protein coding gene	Chr6:57483487-57512537 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030800	protein coding gene	Chr6:57015642-57048828 (-)
A/J	MGP_AJ_G0030772	protein coding gene	Chr6:54416885-54445875 (-)
AKR/J	MGP_AKRJ_G0030696	protein coding gene	Chr6:56259154-56288065 (-)
BALB/cJ	MGP_BALBcJ_G0030783	protein coding gene	Chr6:54801267-54829521 (-)
C3H/HeJ	MGP_C3HHeJ_G0030496	protein coding gene	Chr6:56326361-56362808 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031238	protein coding gene	Chr6:58321875-58350979 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028445	protein coding gene	Chr6:52633985-52659075 (+)
CAST/EiJ	MGP_CASTEiJ_G0029892	protein coding gene	Chr6:56074019-56102043 (-)
CBA/J	MGP_CBAJ_G0030467	protein coding gene	Chr6:60746439-60784078 (-)
DBA/2J	MGP_DBA2J_G0030618	protein coding gene	Chr6:54263425-54291068 (-)
FVB/NJ	MGP_FVBNJ_G0030571	protein coding gene	Chr6:53869929-53899201 (-)
LP/J	MGP_LPJ_G0030703	protein coding gene	Chr6:56956599-56988511 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030605	protein coding gene	Chr6:63185015-63217313 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031262	protein coding gene	Chr6:56160909-56234039 (-)
PWK/PhJ	MGP_PWKPhJ_G0029610	protein coding gene	Chr6:53996085-54026257 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029437	protein coding gene	Chr6:55483422-55511023 (-)
WSB/EiJ	MGP_WSBEiJ_G0029973	protein coding gene	Chr6:56270527-56303173 (-)

Human Ortholog

PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K
Synonyms

BCKDH, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07
Links

HGNC:25415

NCBI Gene ID: 152926

neXtProt AC: NX_Q8N3J5

UniProt: Q8N3J5
Chr Location

4q22.1; chr4:88257620-88284769 (-) GRCh38

MGI Vertebrate Homology

Ppm1k stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPM1K
Gene Tree

Ppm1k

Diseases

1 with Ppm1k mouse models; 1 with human PPM1K associations

Human Disease

Mouse Models

maple syrup urine disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

4
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit defective amino acid metabolism, increased oxidative stress, and increased mortality when subjected to a high-protein diet while in utero and during postnatal development.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

25
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppm1k

ZFIN ppm1kb

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All Sequences

46
RefSeq

9
UniProt

3
CCDS

CCDS20183.1

Ensembl

ENSMUSG00000037826 (Evidence)
NCBI Gene

243382

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037826	Ensembl Gene Model \| MGI Sequence Detail	28967	C57BL/6J	± kb
transcript	ENSMUST00000042766	Ensembl \| MGI Sequence Detail	5560	Not Applicable
polypeptide	ENSMUSP00000041395	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013098 protein phosphatase Mn(2+)-dependent 1K

(term hierarchy)
EC

3.1.3.16, 3.1.3.52
InterPro Domains

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

IPR015655 Protein phosphatase 2C

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 3

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MGI:1920294

Summaries

All 47

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 22
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348563 Yao CC, et al., Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8(+) T cells with enhanced effector function and anti-tumor response. Cell Rep. 2023 Mar 3;42(3):112186

TSS for Ppm1k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61160	Chr6:57512484-57512498 (-)	-38 bp
Tssr61159	Chr6:57512462-57512482 (-)	-19 bp
Tssr61158	Chr6:57512407-57512432 (-)	33 bp
Tssr61157	Chr6:57512395-57512406 (-)	52 bp
Tssr61156	Chr6:57512353-57512380 (-)	86 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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