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Itga11 Gene Detail
Summary
  • Symbol
    Itga11
  • Name
    integrin alpha 11
  • Synonyms
    4732459H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442114
    NCBI Gene: 319480
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62585108-62691264 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3220 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442114
 protein coding gene Chr9:62585108-62691618 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034922
 protein coding gene Chr9:62223354-62340823 (+)
A/J MGP_AJ_G0034902
 protein coding gene Chr9:60174930-60284607 (+)
AKR/J MGP_AKRJ_G0034832
 protein coding gene Chr9:61570673-61688870 (+)
BALB/cJ MGP_BALBcJ_G0034895
 protein coding gene Chr9:59896505-60013942 (+)
C3H/HeJ MGP_C3HHeJ_G0034605
 protein coding gene Chr9:62084959-62200361 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035414
 protein coding gene Chr9:63938755-64061300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032325
 protein coding gene Chr9:59837767-59944858 (+)
CAST/EiJ MGP_CASTEiJ_G0033926
 protein coding gene Chr9:62214818-62344815 (+)
CBA/J MGP_CBAJ_G0034576
 protein coding gene Chr9:66131554-66261742 (+)
DBA/2J MGP_DBA2J_G0034735
 protein coding gene Chr9:59976032-60084256 (+)
FVB/NJ MGP_FVBNJ_G0034677
 protein coding gene Chr9:59257874-59367806 (+)
LP/J MGP_LPJ_G0034818
 protein coding gene Chr9:62516972-62636858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034720
 protein coding gene Chr9:67499448-67615098 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035436
 protein coding gene Chr9:61642297-61752828 (+)
PWK/PhJ MGP_PWKPhJ_G0033630
 protein coding gene Chr9:60095390-60214243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033463
 protein coding gene Chr9:61932669-62062697 (+)
WSB/EiJ MGP_WSBEiJ_G0034039
 protein coding gene Chr9:61559543-61677800 (+)



Homology
more
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
  • Synonyms
    HsT18964
  • Links
    NCBI Gene ID: 22801
    neXtProt AC: NX_Q9UKX5
    UniProt: Q9UKX5

  • Chr Location
    15q23; chr15:68296532-68432163 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ITGA11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    39
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032243 Ensembl Gene Model | MGI Sequence Detail 106157 C57BL/6J ±  kb
    transcript ENSMUST00000034774 Ensembl | MGI Sequence Detail 4969 Not Applicable  
    polypeptide ENSMUSP00000034774 Ensembl | MGI Sequence Detail 1188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory