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Arhgef18 Gene Detail
Summary
  • Symbol
    Arhgef18
  • Name
    Rho/Rac guanine nucleotide exchange factor 18
  • Synonyms
    A430078G23Rik, D030053O22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142567
    NCBI Gene: 102098
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3403415-3506601 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2396 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142567
 protein coding gene Chr8:3403339-3506601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033301
 protein coding gene Chr8:255040-362199 (+)
A/J MGP_AJ_G0033284
 protein coding gene Chr8:261199-365638 (+)
AKR/J MGP_AKRJ_G0033215
 protein coding gene Chr8:273553-378277 (+)
BALB/cJ MGP_BALBcJ_G0033284
 protein coding gene Chr8:287695-392750 (+)
C3H/HeJ MGP_C3HHeJ_G0032998
 protein coding gene Chr8:322019-387988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033794
 protein coding gene Chr8:329048-399694 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030767
 protein coding gene Chr8:252928-316865 (+)
CAST/EiJ MGP_CASTEiJ_G0032321
 protein coding gene Chr8:276433-390387 (+)
CBA/J MGP_CBAJ_G0032971
 protein coding gene Chr8:277816-405652 (+)
DBA/2J MGP_DBA2J_G0033125
 protein coding gene Chr8:229096-333215 (+)
FVB/NJ MGP_FVBNJ_G0033072
 protein coding gene Chr8:281657-387105 (+)
LP/J MGP_LPJ_G0033217
 protein coding gene Chr8:253737-362614 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033107
 protein coding gene Chr8:297476-406210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033812
 protein coding gene Chr8:244618-363444 (+)
PWK/PhJ MGP_PWKPhJ_G0032031
 protein coding gene Chr8:248975-355261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031875
 protein coding gene Chr8:295168-363557 (+)
WSB/EiJ MGP_WSBEiJ_G0032434
 protein coding gene Chr8:298414-366531 (+)



Homology
more
  • Human Ortholog
    ARHGEF18, Rho/Rac guanine nucleotide exchange factor 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF18, Rho/Rac guanine nucleotide exchange factor 18
  • Synonyms
    p114RhoGEF, P114-RhoGEF, RP78, SA-RhoGEF
  • Links
    NCBI Gene ID: 23370
    neXtProt AC: NX_Q6ZSZ5
    UniProt: Q6ZSZ5

  • Chr Location
    19p13.2; chr19:7348937-7479989 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARHGEF18 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion exhibit greatly reduced viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    8
  • cDNA Data
    71
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004568 Ensembl Gene Model | MGI Sequence Detail 103187 C57BL/6J ±  kb
    transcript ENSMUST00000239102 Ensembl | MGI Sequence Detail 6574 Not Applicable  
    polypeptide ENSMUSP00000158969 Ensembl | MGI Sequence Detail 1405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442135
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory