Gak MGI Mouse Gene Detail - MGI:2442153 - cyclin G associated kinase

Symbol

Gak
Name

cyclin G associated kinase
Synonyms

D130045N16Rik, MGC:31204

Feature Type

protein coding gene
IDs

MGI:2442153
NCBI Gene: 231580
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:108717277-108777621 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.20 cM
Mapping Data

1 experiment

SNPs within 2kb

1478 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442153	protein coding gene	Chr5:108716973-108777643 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029859	protein coding gene	Chr5:110691826-110758992 (-)
A/J	MGP_AJ_G0029823	protein coding gene	Chr5:106435546-106496197 (-)
AKR/J	MGP_AKRJ_G0029768	protein coding gene	Chr5:109861678-109925884 (-)
BALB/cJ	MGP_BALBcJ_G0029835	protein coding gene	Chr5:107574953-107635884 (-)
C3H/HeJ	MGP_C3HHeJ_G0029557	protein coding gene	Chr5:110360116-110428230 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030289	protein coding gene	Chr5:115210837-115277714 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027523	protein coding gene	Chr5:101449355-101512817 (-)
CAST/EiJ	MGP_CASTEiJ_G0028971	protein coding gene	Chr5:109249175-109311756 (-)
CBA/J	MGP_CBAJ_G0029525	protein coding gene	Chr5:119099833-119168862 (-)
DBA/2J	MGP_DBA2J_G0029671	protein coding gene	Chr5:106563007-106623908 (-)
FVB/NJ	MGP_FVBNJ_G0029628	protein coding gene	Chr5:105290000-105354023 (-)
LP/J	MGP_LPJ_G0029759	protein coding gene	Chr5:111274785-111337582 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029660	protein coding gene	Chr5:123990063-124054076 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030323	protein coding gene	Chr5:109419203-109479231 (-)
PWK/PhJ	MGP_PWKPhJ_G0028684	protein coding gene	Chr5:105383770-105445986 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028522	protein coding gene	Chr5:106946841-107010847 (-)
WSB/EiJ	MGP_WSBEiJ_G0029044	protein coding gene	Chr5:109739440-109802967 (-)

Human Ortholog

GAK, cyclin G associated kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAK, cyclin G associated kinase
Synonyms

DNAJ26, DNAJC26
Links

HGNC:4113

NCBI Gene ID: 2580

neXtProt AC: NX_O14976

UniProt: O14976
Chr Location

4p16.3; chr4:849276-932373 (-) GRCh38

MGI Vertebrate Homology

Gak stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GAK
Gene Tree

Gak

less

Phenotype Summary

45 phenotypes from 4 alleles in 6 genetic backgrounds
3 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Gak
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a deletion of the kinase domain display neonatal lethality with abnormal lung alveolar morphology and development. Mice homozygous for a knock-out allele exhibit lethality during early development.

less

All GO Annotations

71
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

37
cDNA Data

148
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gak

ZFIN gak

less

All Sequences

113
RefSeq

24
UniProt

10
CCDS

CCDS19513.1

Ensembl

ENSMUSG00000062234 (Evidence)
NCBI Gene

231580

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062234	Ensembl Gene Model \| MGI Sequence Detail	60345	C57BL/6J	± kb
transcript	ENSMUST00000046603	Ensembl \| MGI Sequence Detail	4453	Not Applicable
polypeptide	ENSMUSP00000036705	Ensembl \| MGI Sequence Detail	1305	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000007805 cyclin-G-associated kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR035892 C2 domain superfamily

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR029021 Protein-tyrosine phosphatase-like

IPR008271 Serine/threonine-protein kinase, active site

IPR014020 Tensin phosphatase, C2 domain

IPR029023 Tensin-type phosphatase domain
GlyGen

Q99KY4 6 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)

less

All nucleic 149

cDNA 149

Microarray probesets 5

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:301922 Tian X, et al., Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. JCI Insight. 2020 Nov 19;5(22)

TSS for Gak:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52445	Chr5:108777578-108777627 (-)	18 bp
Tssr52444	Chr5:108777552-108777573 (-)	58 bp
Tssr52443	Chr5:108777537-108777544 (-)	80 bp
Tssr52442	Chr5:108742284-108742288 (-)	35,335 bp
Tssr52441	Chr5:108735680-108735685 (-)	41,938 bp
Tssr52440	Chr5:108730726-108730745 (-)	46,885 bp
Tssr52439	Chr5:108730007-108730030 (-)	47,602 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24