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Ppp6r1 Gene Detail
Summary
  • Symbol
    Ppp6r1
  • Name
    protein phosphatase 6, regulatory subunit 1
  • Synonyms
    2010309P17Rik, B430201G11Rik, mKIAA1115, Pp6r1, Saps1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442163
    NCBI Gene: 243819
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4634494-4661949 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442163
 protein coding gene Chr7:4634494-4662018 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031553
 protein coding gene Chr7:1551374-1576507 (-)
A/J MGP_AJ_G0031527
 protein coding gene Chr7:1564524-1590695 (-)
AKR/J MGP_AKRJ_G0031456
 protein coding gene Chr7:1626146-1651280 (-)
BALB/cJ MGP_BALBcJ_G0031535
 protein coding gene Chr7:1607640-1632726 (-)
C3H/HeJ MGP_C3HHeJ_G0031256
 protein coding gene Chr7:1601704-1629439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031996
 protein coding gene Chr7:1609695-1637229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029120
 protein coding gene Chr7:1316064-1344016 (-)
CAST/EiJ MGP_CASTEiJ_G0030620
 protein coding gene Chr7:1539220-1567342 (-)
CBA/J MGP_CBAJ_G0031214
 protein coding gene Chr7:1797330-1829214 (-)
DBA/2J MGP_DBA2J_G0031373
 protein coding gene Chr7:1541009-1573052 (-)
FVB/NJ MGP_FVBNJ_G0031325
 protein coding gene Chr7:1510797-1536556 (-)
LP/J MGP_LPJ_G0031458
 protein coding gene Chr7:1663766-1691800 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031364
 protein coding gene Chr7:1734622-1765496 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032026
 protein coding gene Chr7:1536153-1565333 (-)
PWK/PhJ MGP_PWKPhJ_G0030348
 protein coding gene Chr7:1711274-1739378 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030173
 protein coding gene Chr7:1590658-1618872 (-)
WSB/EiJ MGP_WSBEiJ_G0030715
 protein coding gene Chr7:1551356-1580970 (-)



Homology
more
  • Human Ortholog
    PPP6R1, protein phosphatase 6 regulatory subunit 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP6R1, protein phosphatase 6 regulatory subunit 1
  • Synonyms
    KIAA1115, PP6R1, SAP190, SAPS1
  • Links
    NCBI Gene ID: 22870
    neXtProt AC: NX_Q9UPN7
    UniProt: Q9UPN7

  • Chr Location
    19q13.42; chr19:55228218-55259017 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 243819 NCBI Gene Model | MGI Sequence Detail 27456 C57BL/6J ±  kb
transcript NM_172894 RefSeq | MGI Sequence Detail 3812 C57BL/6  
polypeptide Q7TSI3 UniProt | EBI | MGI Sequence Detail 856 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000014451 serine/threonine-protein phosphatase 6 regulatory subunit 1
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR007587 SIT4 phosphatase-associated protein family
  • GlyGen
    Q7TSI3 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924003, MGI:2142035
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:296775 Dziegielewski J, et al., Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. DNA Repair (Amst). 2020 Jan;85:102737
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory