Tarm1 MGI Mouse Gene Detail - MGI:2442280 - T cell-interacting, activating receptor on myeloid cells 1

Symbol

Tarm1
Name

T cell-interacting, activating receptor on myeloid cells 1
Synonyms

9930022N03Rik, Gm9904

Feature Type

protein coding gene
IDs

MGI:2442280
NCBI Gene: 245126
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:3535016-3551140 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.04 cM
Mapping Data

1 experiment

SNPs within 2kb

628 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442280	protein coding gene	Chr7:3535015-3551159 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031520	protein coding gene	Chr7:406375-421106 (-)
A/J	MGP_AJ_G0031495	protein coding gene	Chr7:395664-412227 (-)
AKR/J	MGP_AKRJ_G0031423	protein coding gene	Chr7:395349-420563 (-)
BALB/cJ	MGP_BALBcJ_G0031503	protein coding gene	Chr7:402533-421174 (-)
C3H/HeJ	MGP_C3HHeJ_G0031223	protein coding gene	Chr7:409695-425932 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031963	protein coding gene	Chr7:428203-443494 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029090	protein coding gene	Chr7:295738-313989 (-)
CAST/EiJ	MGP_CASTEiJ_G0030592	protein coding gene	Chr7:407568-422834 (-)
CBA/J	MGP_CBAJ_G0031183	protein coding gene	Chr7:530999-547148 (-)
DBA/2J	MGP_DBA2J_G0031340	protein coding gene	Chr7:393043-407983 (-)
FVB/NJ	MGP_FVBNJ_G0031292	protein coding gene	Chr7:385664-403962 (-)
LP/J	MGP_LPJ_G0031425	protein coding gene	Chr7:413728-427972 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031331	protein coding gene	Chr7:447556-466112 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031997	protein coding gene	Chr7:393919-410496 (-)
PWK/PhJ	MGP_PWKPhJ_G0030319	protein coding gene	Chr7:535183-551126 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030143	protein coding gene	Chr7:464011-480388 (-)
WSB/EiJ	MGP_WSBEiJ_G0030686	protein coding gene	Chr7:400034-415067 (-)

Human Ortholog

TARM1, T cell-interacting, activating receptor on myeloid cells 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TARM1, T cell-interacting, activating receptor on myeloid cells 1
Synonyms

OLT-2
Links

HGNC:37250

NCBI Gene ID: 441864

neXtProt AC: NX_B6A8C7

UniProt: B6A8C7
Chr Location

19q13.42; chr19:54069895-54081365 (-) GRCh38

MGI Vertebrate Homology

Tarm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TARM1
Gene Tree

Tarm1

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased susceptibility to collagen-induced arthritis with dendritic cells showing impaired antigen presentation.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

6
UniProt

3
CCDS

CCDS39727.1, CCDS90146.1

Ensembl

ENSMUSG00000053338 (Evidence)
NCBI Gene

245126

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053338	Ensembl Gene Model \| MGI Sequence Detail	16125	C57BL/6J	± kb
transcript	ENSMUST00000203020	Ensembl \| MGI Sequence Detail	1487	Not Applicable
polypeptide	ENSMUSP00000145188	Ensembl \| MGI Sequence Detail	293	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031840 T-cell-interacting, activating receptor on myeloid cells protein 1

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR050412 Immunoglobulin-like Receptors in Immune Regulation

IPR003599 Immunoglobulin subtype
GlyGen

B6A8R8 2 sites

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 23

Gene Ontology 4

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tarm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2068	Chr7:3551271-3551282 (-)	-137 bp
Tssr70409	Chr7:3551133-3551145 (-)	1 bp
Tssr70408	Chr7:3551103-3551108 (-)	34 bp
Tssr70407	Chr7:3551058-3551094 (-)	64 bp
Tssr70406	Chr7:3551018-3551026 (-)	118 bp
Tssr2067	Chr7:3546320-3546327 (-)	4,816 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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