Usp28 MGI Mouse Gene Detail - MGI:2442293 - ubiquitin specific peptidase 28

Symbol

Usp28
Name

ubiquitin specific peptidase 28
Synonyms

9830148O20Rik, mKIAA1515

Feature Type

protein coding gene
IDs

MGI:2442293
NCBI Gene: 235323
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:48896675-48953817 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 26.56 cM
Mapping Data

2 experiments

SNPs within 2kb

1358 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442293	protein coding gene	Chr9:48896577-48953817 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034767	protein coding gene	Chr9:47783679-47855673 (+)
A/J	MGP_AJ_G0034748	protein coding gene	Chr9:46367492-46428784 (+)
AKR/J	MGP_AKRJ_G0034676	protein coding gene	Chr9:47338643-47399032 (+)
BALB/cJ	MGP_BALBcJ_G0034740	protein coding gene	Chr9:46090742-46149948 (+)
C3H/HeJ	MGP_C3HHeJ_G0034450	protein coding gene	Chr9:47793268-47851430 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035260	protein coding gene	Chr9:49153225-49213869 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032173	protein coding gene	Chr9:45857450-45915204 (+)
CAST/EiJ	MGP_CASTEiJ_G0033772	protein coding gene	Chr9:47741381-47798315 (+)
CBA/J	MGP_CBAJ_G0034422	protein coding gene	Chr9:50891589-50962722 (+)
DBA/2J	MGP_DBA2J_G0034581	protein coding gene	Chr9:46226608-46283538 (+)
FVB/NJ	MGP_FVBNJ_G0034522	protein coding gene	Chr9:45473332-45531792 (+)
LP/J	MGP_LPJ_G0034662	protein coding gene	Chr9:48164524-48224487 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034566	protein coding gene	Chr9:52580045-52645607 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035281	protein coding gene	Chr9:47272656-47339843 (+)
PWK/PhJ	MGP_PWKPhJ_G0033477	protein coding gene	Chr9:46192238-46250131 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033312	protein coding gene	Chr9:47587041-47650746 (+)
WSB/EiJ	MGP_WSBEiJ_G0033885	protein coding gene	Chr9:47313569-47372778 (+)

Human Ortholog

USP28, ubiquitin specific peptidase 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP28, ubiquitin specific peptidase 28
Links

HGNC:12625

NCBI Gene ID: 57646

neXtProt AC: NX_Q96RU2

UniProt: Q96RU2
Chr Location

11q23.2; chr11:113797874-113875572 (-) GRCh38

MGI Vertebrate Homology

Usp28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP28
Gene Tree

Usp28

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

72
Endonuclease-mediated

4
Gene trapped

67
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile and exhibit slightly decreased spleen weight and splenocyte number but show neither major signaling defects in DNA damage response nor developmental defects indicative of impaired double-strand break metabolism.

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All GO Annotations

29
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

23
cDNA Data

124
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp28

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All Sequences

74
RefSeq

18
UniProt

6
CCDS

CCDS40613.1

Ensembl

ENSMUSG00000032267 (Evidence)
NCBI Gene

235323

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032267	Ensembl Gene Model \| MGI Sequence Detail	57143	C57BL/6J	± kb
transcript	ENSMUST00000047349	Ensembl \| MGI Sequence Detail	4133	Not Applicable
polypeptide	ENSMUSP00000047467	Ensembl \| MGI Sequence Detail	1051	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017166 ubiquitin carboxyl-terminal hydrolase 28

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR009060 UBA-like superfamily

IPR044635 Ubiquitin carboxyl-terminal hydrolase 14-like

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

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All nucleic 128

cDNA 124

Primer pair 4

Microarray probesets 3

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MGI:2143214

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 17
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:340706 Cai C, et al., USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice. Nat Commun. 2023 Jun 20;14(1):3648

TSS for Usp28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84998	Chr9:48896658-48896751 (+)	30 bp
Tssr84999	Chr9:48896767-48896778 (+)	98 bp
Tssr85000	Chr9:48898728-48898736 (+)	2,057 bp
Tssr85001	Chr9:48903287-48903305 (+)	6,621 bp
Tssr85002	Chr9:48913885-48913888 (+)	17,212 bp
Tssr85003	Chr9:48939428-48939440 (+)	42,759 bp
Tssr85004	Chr9:48942176-48942183 (+)	45,505 bp
Tssr85005	Chr9:48948581-48948583 (+)	51,907 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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