Zbtb1 MGI Mouse Gene Detail - MGI:2442326 - zinc finger and BTB domain containing 1

Symbol

Zbtb1
Name

zinc finger and BTB domain containing 1
Synonyms

C430003J21Rik

Feature Type

protein coding gene
IDs

MGI:2442326
NCBI Gene: 268564
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:76417040-76443724 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

2 experiments

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442326	protein coding gene	Chr12:76416825-76443729 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019857	protein coding gene	Chr12:76482035-76508592 (+)
A/J	MGP_AJ_G0019815	protein coding gene	Chr12:73576826-73603542 (+)
AKR/J	MGP_AKRJ_G0019790	protein coding gene	Chr12:75804199-75830751 (+)
BALB/cJ	MGP_BALBcJ_G0019794	protein coding gene	Chr12:74050527-74077450 (+)
C3H/HeJ	MGP_C3HHeJ_G0019600	protein coding gene	Chr12:76262402-76289944 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020246	protein coding gene	Chr12:78824223-78853729 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017864	protein coding gene	Chr12:70908181-70934664 (+)
CAST/EiJ	MGP_CASTEiJ_G0019151	protein coding gene	Chr12:71073357-71100979 (+)
CBA/J	MGP_CBAJ_G0019570	protein coding gene	Chr12:81872992-81900474 (+)
DBA/2J	MGP_DBA2J_G0019686	protein coding gene	Chr12:73425026-73452111 (+)
FVB/NJ	MGP_FVBNJ_G0019673	protein coding gene	Chr12:72268624-72295439 (+)
LP/J	MGP_LPJ_G0019758	protein coding gene	Chr12:76456774-76484605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019712	protein coding gene	Chr12:84899356-84921283 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020282	protein coding gene	Chr12:75277267-75303784 (+)
PWK/PhJ	MGP_PWKPhJ_G0018917	protein coding gene	Chr12:67797033-67823785 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018711	protein coding gene	Chr12:69796611-69823138 (+)
WSB/EiJ	MGP_WSBEiJ_G0019203	protein coding gene	Chr12:75893896-75923859 (+)

Human Ortholog

ZBTB1, zinc finger and BTB domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB1, zinc finger and BTB domain containing 1
Synonyms

ZNF909
Links

HGNC:20259

NCBI Gene ID: 22890

neXtProt AC: NX_Q9Y2K1

UniProt: Q9Y2K1
Chr Location

14q23.3; chr14:64503712-64533693 (+) GRCh38

MGI Vertebrate Homology

Zbtb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB1
Gene Tree

Zbtb1

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

122
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

111
Targeted

5
Genomic Mutations

1 involving Zbtb1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

115 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU induced mutation exhibit abnormal thymus, B cell, and T cell differentiation, and reduced numbers of T, B, and NK cells in the spleen.

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All GO Annotations

47
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

49
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zbtb1

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All Sequences

47
RefSeq

10
UniProt

3
CCDS

CCDS25992.1

Ensembl

ENSMUSG00000033454 (Evidence)
NCBI Gene

268564

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033454	Ensembl Gene Model \| MGI Sequence Detail	26685	C57BL/6J	± kb
transcript	ENSMUST00000042779	Ensembl \| MGI Sequence Detail	12190	Not Applicable
polypeptide	ENSMUSP00000041955	Ensembl \| MGI Sequence Detail	713	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017561 zinc finger and BTB domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 14

cDNA 11

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2144776

Summaries

All 50

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:308922 Medeiros de Araujo JA, et al., ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development. 2021 Aug 15;148(16):dev196642

TSS for Zbtb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113957	Chr12:76417250-76417282 (+)	226 bp
Tssr113958	Chr12:76417287-76417302 (+)	255 bp
Tssr113959	Chr12:76417311-76417394 (+)	313 bp
Tssr113960	Chr12:76417901-76417914 (+)	868 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24