Stk32a MGI Mouse Gene Detail - MGI:2442403 - serine/threonine kinase 32A

Symbol

Stk32a
Name

serine/threonine kinase 32A
Synonyms

A930015B13Rik, YANK1

Feature Type

protein coding gene
IDs

MGI:2442403
NCBI Gene: 269019
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr18:43340762-43450546 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 23.17 cM
Mapping Data

2 experiments

SNPs within 2kb

3362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442403	protein coding gene	Chr18:43340648-43451747 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024384	protein coding gene	Chr18:41883150-42017431 (+)
A/J	MGP_AJ_G0024351	protein coding gene	Chr18:40425298-40544846 (+)
AKR/J	MGP_AKRJ_G0024320	protein coding gene	Chr18:41534359-41657096 (+)
BALB/cJ	MGP_BALBcJ_G0024351	protein coding gene	Chr18:40515995-40630504 (+)
C3H/HeJ	MGP_C3HHeJ_G0024117	protein coding gene	Chr18:41597330-41716749 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024793	protein coding gene	Chr18:43367776-43489837 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022231	protein coding gene	Chr18:40232563-40348137 (+)
CAST/EiJ	MGP_CASTEiJ_G0023592	protein coding gene	Chr18:41581300-41701153 (+)
CBA/J	MGP_CBAJ_G0024087	protein coding gene	Chr18:44602119-44717189 (+)
DBA/2J	MGP_DBA2J_G0024217	protein coding gene	Chr18:40024306-40134306 (+)
FVB/NJ	MGP_FVBNJ_G0024183	protein coding gene	Chr18:39629868-39740934 (+)
LP/J	MGP_LPJ_G0024301	protein coding gene	Chr18:41938651-42057654 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024214	protein coding gene	Chr18:45891335-46018524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024842	protein coding gene	Chr18:41417893-41538743 (+)
PWK/PhJ	MGP_PWKPhJ_G0023336	protein coding gene	Chr18:40234050-40348753 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023141	protein coding gene	Chr18:41653832-41777514 (+)
WSB/EiJ	MGP_WSBEiJ_G0023655	protein coding gene	Chr18:41342238-41460837 (+)

Human Ortholog

STK32A, serine/threonine kinase 32A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK32A, serine/threonine kinase 32A
Synonyms

YANK1
Links

HGNC:28317

NCBI Gene ID: 202374

neXtProt AC: NX_Q8WU08

UniProt: Q8WU08
Chr Location

5q32; chr5:147234963-147401990 (+) GRCh38

MGI Vertebrate Homology

Stk32a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STK32A
Gene Tree

Stk32a

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available

Homozygous knock-out mice show disruption of the planar polarized organization of vestibular hair cells in the utricle.

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk32a

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS29218.1

Ensembl

ENSMUSG00000039954 (Evidence)
NCBI Gene

269019

			Length	Strain/Species	Flank
genomic	269019	NCBI Gene Model \| MGI Sequence Detail	109785	C57BL/6J	± kb
transcript	NM_178749	RefSeq \| MGI Sequence Detail	3765	C57BL/6
polypeptide	Q8BGW6	UniProt \| EBI \| MGI Sequence Detail	398	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015748 serine/threonine-protein kinase 32A

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 8

cDNA 8

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stk32a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150886	Chr18:43340590-43340603 (+)	-165 bp
Tssr150887	Chr18:43340616-43340628 (+)	-140 bp
Tssr150888	Chr18:43340687-43340743 (+)	-47 bp
Tssr150889	Chr18:43340744-43340765 (+)	-7 bp
Tssr150890	Chr18:43340775-43340786 (+)	19 bp
Tssr150891	Chr18:43340789-43340802 (+)	34 bp
Tssr150892	Chr18:43398853-43398861 (+)	58,095 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24