Ust MGI Mouse Gene Detail - MGI:2442406 - uronyl-2-sulfotransferase

Symbol

Ust
Name

uronyl-2-sulfotransferase
Synonyms

D930010O20Rik, UA2OST

Feature Type

protein coding gene
IDs

MGI:2442406
NCBI Gene: 338362
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:8080520-8394589 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.65 cM
Mapping Data

1 experiment

SNPs within 2kb

9317 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442406	protein coding gene	Chr10:8068499-8394701 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017003	protein coding gene	Chr10:5467408-5795854 (-)
A/J	MGP_AJ_G0016981	protein coding gene	Chr10:5192983-5501468 (-)
AKR/J	MGP_AKRJ_G0016945	protein coding gene	Chr10:5295226-5587743 (-)
BALB/cJ	MGP_BALBcJ_G0016939	protein coding gene	Chr10:5162787-5451158 (-)
C3H/HeJ	MGP_C3HHeJ_G0016764	protein coding gene	Chr10:5441147-5769972 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017401	protein coding gene	Chr10:5594447-5920262 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015106	protein coding gene	Chr10:4762372-5056179 (-)
CAST/EiJ	MGP_CASTEiJ_G0016346	protein coding gene	Chr10:5351337-5662227 (-)
CBA/J	MGP_CBAJ_G0016736	protein coding gene	Chr10:5789642-6121651 (-)
DBA/2J	MGP_DBA2J_G0016844	protein coding gene	Chr10:5119525-5423304 (-)
FVB/NJ	MGP_FVBNJ_G0016839	protein coding gene	Chr10:5063489-5372808 (-)
LP/J	MGP_LPJ_G0016919	protein coding gene	Chr10:5290273-5614986 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016869	protein coding gene	Chr10:5704723-6035555 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017439	protein coding gene	Chr10:5252787-5567559 (-)
PWK/PhJ	MGP_PWKPhJ_G0016131	protein coding gene	Chr10:5088023-5386680 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015913	protein coding gene	Chr10:5327451-5648104 (-)
WSB/EiJ	MGP_WSBEiJ_G0016408	protein coding gene	Chr10:5257982-5581009 (-)

Human Ortholog

UST, uronyl 2-sulfotransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UST, uronyl 2-sulfotransferase
Synonyms

2OST
Links

HGNC:17223

NCBI Gene ID: 10090

neXtProt AC: NX_Q9Y2C2

UniProt: Q9Y2C2
Chr Location

6q25.1; chr6:148747030-149076990 (+) GRCh38

MGI Vertebrate Homology

Ust stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UST
Gene Tree

Ust

Diseases

1 with human UST associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

821
Tissues

105
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ust

ZFIN usta

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS35835.1

Ensembl

ENSMUSG00000047712 (Evidence)
NCBI Gene

338362

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047712	Ensembl Gene Model \| MGI Sequence Detail	314070	C57BL/6J	± kb
transcript	ENSMUST00000061601	Ensembl \| MGI Sequence Detail	4228	Not Applicable
polypeptide	ENSMUSP00000052017	Ensembl \| MGI Sequence Detail	407	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017199 uronyl 2-sulfotransferase

(term hierarchy)
EC

2.8.2.-
InterPro Domains

IPR007734 Heparan sulphate 2-O-sulfotransferase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR005331 Sulfotransferase
GlyGen

Q8BUB6 5 sites, 5 N-linked glycans (5 sites)

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ust:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96633	Chr10:8394565-8394615 (-)	-1 bp
Tssr96632	Chr10:8394546-8394564 (-)	34 bp
Tssr96631	Chr10:8394239-8394255 (-)	342 bp
Tssr96630	Chr10:8387385-8387391 (-)	7,201 bp
Tssr96629	Chr10:8347580-8347586 (-)	47,006 bp
Tssr96628	Chr10:8328783-8328812 (-)	65,791 bp
Tssr96627	Chr10:8327586-8327590 (-)	67,001 bp
Tssr96626	Chr10:8234089-8234120 (-)	160,484 bp
Tssr96625	Chr10:8165988-8165993 (-)	228,598 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24