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Dpp10 Gene Detail
Summary
  • Symbol
    Dpp10
  • Name
    dipeptidylpeptidase 10
  • Synonyms
    6430601K09Rik, DPRP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442409
    NCBI Gene: 269109
  • Alliance
    gene page
  • Transcription Start Sites
    70 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:123259871-124773774 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 53.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442409
 protein coding gene Chr1:123249200-124773776 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016413
 protein coding gene Chr1:126277450-127053062 (-)
A/J MGP_AJ_G0016396
 protein coding gene Chr1:121694113-122426919 (-)
AKR/J MGP_AKRJ_G0016361
 protein coding gene Chr1:125247361-126012082 (-)
BALB/cJ MGP_BALBcJ_G0016356
 protein coding gene Chr1:121997531-122751717 (-)
C3H/HeJ MGP_C3HHeJ_G0016182
 protein coding gene Chr1:125463167-126226313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016817
 protein coding gene Chr1:131066973-131856097 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014530
 protein coding gene Chr1:115225936-115924735 (-)
CAST/EiJ MGP_CASTEiJ_G0015763
 protein coding gene Chr1:124304649-125107512 (-)
CBA/J MGP_CBAJ_G0016155
 protein coding gene Chr1:135547049-136375629 (-)
DBA/2J MGP_DBA2J_G0016261
 protein coding gene Chr1:120739425-121471350 (-)
FVB/NJ MGP_FVBNJ_G0016260
 protein coding gene Chr1:119456332-120197657 (-)
LP/J MGP_LPJ_G0016332
 protein coding gene Chr1:127602475-128378096 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016285
 protein coding gene Chr1:141386945-142288706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016853
 protein coding gene Chr1:125014257-125780938 (-)
PWK/PhJ MGP_PWKPhJ_G0015549
 protein coding gene Chr1:119693557-120411247 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015337
 protein coding gene Chr1:123953416-124741265 (-)
WSB/EiJ MGP_WSBEiJ_G0015825
 protein coding gene Chr1:124908220-125682437 (-)



Homology
more
  • Human Ortholog
    DPP10, dipeptidyl peptidase like 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP10, dipeptidyl peptidase like 10
  • Synonyms
    DPL2, DPPY, DPRP-3, DPRP3
  • Links
    NCBI Gene ID: 57628
    neXtProt AC: NX_Q8N608
    UniProt: Q8N608

  • Chr Location
    2q14.1; chr2:114442299-115845780 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPP10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Dpp10
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    56 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 269109 NCBI Gene Model | MGI Sequence Detail 1513904 C57BL/6J ±  kb
transcript NM_199021 RefSeq | MGI Sequence Detail 5114 C57BL/6  
polypeptide Q6NXK7 UniProt | EBI | MGI Sequence Detail 797 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006659 inactive dipeptidyl peptidase 10
    (term hierarchy)
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR002469 Dipeptidylpeptidase IV, N-terminal domain
    IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
    IPR050278 Serine Protease S9B/DPPIV Subfamily
  • GlyGen
    Q6NXK7 9 sites, 14 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory