Fbxo48 MGI Mouse Gene Detail - MGI:2442569

Symbol

Fbxo48
Name

F-box protein 48
Synonyms

A630050E13Rik

Feature Type

protein coding gene
IDs

MGI:2442569
NCBI Gene: 319701
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:16901375-16904772 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 9.41 cM
Mapping Data

1 experiment

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442569	protein coding gene	Chr11:16901225-16908516 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018053	protein coding gene	Chr11:14344342-14347739 (+)
A/J	MGP_AJ_G0018026	protein coding gene	Chr11:13852172-13855570 (+)
AKR/J	MGP_AKRJ_G0017990	protein coding gene	Chr11:14350622-14354020 (+)
BALB/cJ	MGP_BALBcJ_G0017994	protein coding gene	Chr11:13971919-13975317 (+)
C3H/HeJ	MGP_C3HHeJ_G0017807	protein coding gene	Chr11:14273882-14277280 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018446	protein coding gene	Chr11:14948223-14951620 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016104	protein coding gene	Chr11:13033756-13037132 (+)
CAST/EiJ	MGP_CASTEiJ_G0017369	protein coding gene	Chr11:14265219-14268617 (+)
CBA/J	MGP_CBAJ_G0017782	protein coding gene	Chr11:15769281-15772676 (+)
DBA/2J	MGP_DBA2J_G0017892	protein coding gene	Chr11:13841140-13844535 (+)
FVB/NJ	MGP_FVBNJ_G0017884	protein coding gene	Chr11:13631116-13634513 (+)
LP/J	MGP_LPJ_G0017963	protein coding gene	Chr11:14506518-14509916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017910	protein coding gene	Chr11:16209279-16216118 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018487	protein coding gene	Chr11:14427794-14431192 (+)
PWK/PhJ	MGP_PWKPhJ_G0017149	protein coding gene	Chr11:13818601-13821999 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016946	protein coding gene	Chr11:14186261-14189645 (+)
WSB/EiJ	MGP_WSBEiJ_G0017423	protein coding gene	Chr11:14128478-14131876 (+)

Human Ortholog

FBXO48, F-box protein 48

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO48, F-box protein 48
Links

HGNC:33857

NCBI Gene ID: 554251

neXtProt AC: NX_Q5FWF7

UniProt: Q5FWF7
Chr Location

2p13.3; chr2:68459422-68467294 (-) GRCh38

MGI Vertebrate Homology

Fbxo48 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FBXO48
Gene Tree

Fbxo48

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Fbxo48
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

4
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

18
UniProt

1
CCDS

CCDS24445.1

Ensembl

ENSMUSG00000044966 (Evidence)
NCBI Gene

319701

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044966	Ensembl Gene Model \| MGI Sequence Detail	3398	C57BL/6J	± kb
transcript	ENSMUST00000109635	Ensembl \| MGI Sequence Detail	1098	Not Applicable
polypeptide	ENSMUSP00000105263	Ensembl \| MGI Sequence Detail	161	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007416 F-box only protein 48

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR045118 F-box only protein FBXO9/FBXO48

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 5
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Fbxo48:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100441	Chr11:16901371-16901417 (+)	19 bp
Tssr100442	Chr11:16901440-16901468 (+)	79 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24