Flywch1 MGI Mouse Gene Detail - MGI:2442638

Symbol

Flywch1
Name

FLYWCH-type zinc finger 1

Feature Type

protein coding gene
IDs

MGI:2442638
NCBI Gene: 224613
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:23971767-23990576 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.04 cM
Mapping Data

1 experiment

SNPs within 2kb

533 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442638	protein coding gene	Chr17:23971767-23993504 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023270	protein coding gene	Chr17:22670800-22690292 (-)
A/J	MGP_AJ_G0023230	protein coding gene	Chr17:22015421-22033875 (-)
AKR/J	MGP_AKRJ_G0023200	protein coding gene	Chr17:22095092-22114222 (-)
BALB/cJ	MGP_BALBcJ_G0023235	protein coding gene	Chr17:22233086-22250669 (-)
C3H/HeJ	MGP_C3HHeJ_G0022995	protein coding gene	Chr17:22453931-22474905 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023678	protein coding gene	Chr17:23658040-23679029 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021159	protein coding gene	Chr17:19581976-19599652 (-)
CAST/EiJ	MGP_CASTEiJ_G0022501	protein coding gene	Chr17:22288028-22308897 (-)
CBA/J	MGP_CBAJ_G0022971	protein coding gene	Chr17:24468191-24493689 (-)
DBA/2J	MGP_DBA2J_G0023103	protein coding gene	Chr17:21646193-21664005 (-)
FVB/NJ	MGP_FVBNJ_G0023070	protein coding gene	Chr17:21371537-21390464 (-)
LP/J	MGP_LPJ_G0023177	protein coding gene	Chr17:22922363-22945138 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023089	protein coding gene	Chr17:24225246-24242550 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023717	protein coding gene	Chr17:22394062-22411664 (-)
PWK/PhJ	MGP_PWKPhJ_G0022249	protein coding gene	Chr17:20431322-20450963 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022069	protein coding gene	Chr17:20410067-20428156 (-)
WSB/EiJ	MGP_WSBEiJ_G0022564	protein coding gene	Chr17:22443706-22461235 (-)

Human Ortholog

FLYWCH1, FLYWCH-type zinc finger 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLYWCH1, FLYWCH-type zinc finger 1
Links

HGNC:25404

NCBI Gene ID: 84256

neXtProt AC: NX_Q4VC44

UniProt: Q4VC44
Chr Location

16p13.3; chr16:2911931-2951208 (+) GRCh38

MGI Vertebrate Homology

Flywch1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FLYWCH1
Gene Tree

Flywch1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

19
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

35
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

72
RefSeq

10
UniProt

4
CCDS

CCDS28463.1

Ensembl

ENSMUSG00000040097 (Evidence)
NCBI Gene

224613

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040097	Ensembl Gene Model \| MGI Sequence Detail	18810	C57BL/6J	± kb
transcript	ENSMUST00000045517	Ensembl \| MGI Sequence Detail	2798	Not Applicable
polypeptide	ENSMUSP00000040022	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007568 FLYWCH-type zinc finger-containing protein 1

(term hierarchy)
InterPro Domains

IPR040312 FLYWCH-type zinc finger-containing protein 1/2

IPR029279 FLYWCH-type zinc finger-containing protein, N-terminal

IPR007588 Zinc finger, FLYWCH-type

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All nucleic 9

cDNA 9

Microarray probesets 6

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Flywch1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146661	Chr17:23990581-23990610 (-)	-20 bp
Tssr146660	Chr17:23990517-23990569 (-)	33 bp
Tssr146659	Chr17:23990479-23990511 (-)	81 bp
Tssr146658	Chr17:23990464-23990473 (-)	107 bp
Tssr146657	Chr17:23974789-23974843 (-)	15,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24