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Ppp2r2c Gene Detail
Summary
  • Symbol
    Ppp2r2c
  • Name
    protein phosphatase 2, regulatory subunit B, gamma
  • Synonyms
    6330548O06Rik, IMYPNO1, PR52
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442660
    NCBI Gene: 269643
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:37025857-37112422 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2611 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442660
 protein coding gene Chr5:37024187-37112422 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029496
 protein coding gene Chr5:35199503-35288770 (+)
A/J MGP_AJ_G0029462
 protein coding gene Chr5:34049517-34135216 (+)
AKR/J MGP_AKRJ_G0029412
 protein coding gene Chr5:35329564-35424596 (+)
BALB/cJ MGP_BALBcJ_G0029473
 protein coding gene Chr5:34548387-34635684 (+)
C3H/HeJ MGP_C3HHeJ_G0029196
 protein coding gene Chr5:35336011-35423012 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029927
 protein coding gene Chr5:37121268-37210483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027165
 protein coding gene Chr5:31772056-31861288 (+)
CAST/EiJ MGP_CASTEiJ_G0028604
 protein coding gene Chr5:34480875-34576170 (+)
CBA/J MGP_CBAJ_G0029163
 protein coding gene Chr5:38031149-38118735 (+)
DBA/2J MGP_DBA2J_G0029310
 protein coding gene Chr5:34175836-34263105 (+)
FVB/NJ MGP_FVBNJ_G0029269
 protein coding gene Chr5:33655634-33743299 (+)
LP/J MGP_LPJ_G0029396
 protein coding gene Chr5:35655738-35748378 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029299
 protein coding gene Chr5:38761995-38854083 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029960
 protein coding gene Chr5:34821517-34915011 (+)
PWK/PhJ MGP_PWKPhJ_G0028328
 protein coding gene Chr5:33358329-33447379 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028161
 protein coding gene Chr5:34298736-34384200 (+)
WSB/EiJ MGP_WSBEiJ_G0028685
 protein coding gene Chr5:34910047-35002575 (+)



Homology
more
  • Human Ortholog
    PPP2R2C, protein phosphatase 2 regulatory subunit Bgamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2C, protein phosphatase 2 regulatory subunit Bgamma
  • Synonyms
    B55gamma, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G
  • Links
    NCBI Gene ID: 5522
    neXtProt AC: NX_Q9Y2T4
    UniProt: Q9Y2T4

  • Chr Location
    4p16.1; chr4:6320578-6563799 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    8 involving Ppp2r2c
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    19
  • cDNA Data
    37
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029120 Ensembl Gene Model | MGI Sequence Detail 86566 C57BL/6J ±  kb
transcript ENSMUST00000031003 Ensembl | MGI Sequence Detail 4088 Not Applicable  
polypeptide ENSMUSP00000031003 Ensembl | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013137 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    (term hierarchy)
  • InterPro Domains
    IPR000009 Protein phosphatase 2A regulatory subunit PR55
    IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q8BG02 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 53
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 2
    Phenotypes 23
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:339532 Li J, et al., Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons. PLoS Genet. 2021 Mar;17(3):e1009355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory