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Naprt Gene Detail
Summary
  • Symbol
    Naprt
  • Name
    nicotinate phosphoribosyltransferase
  • Synonyms
    9130210N20Rik, Naprt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442664
    NCBI Gene: 223646
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75762812-75766330 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442664
 protein coding gene Chr15:75762805-75766330 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021962
 protein coding gene Chr15:75938498-75942015 (-)
A/J MGP_AJ_G0021920
 protein coding gene Chr15:73172897-73176414 (-)
AKR/J MGP_AKRJ_G0021903
 protein coding gene Chr15:75151715-75155232 (-)
BALB/cJ MGP_BALBcJ_G0021929
 protein coding gene Chr15:73193655-73197172 (-)
C3H/HeJ MGP_C3HHeJ_G0021701
 protein coding gene Chr15:75212721-75216238 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022369
 protein coding gene Chr15:78777047-78780564 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019900
 protein coding gene Chr15:69845215-69848920 (-)
CAST/EiJ MGP_CASTEiJ_G0021220
 protein coding gene Chr15:75995624-75999138 (-)
CBA/J MGP_CBAJ_G0021668
 protein coding gene Chr15:81291535-81295052 (-)
DBA/2J MGP_DBA2J_G0021793
 protein coding gene Chr15:72703660-72707177 (-)
FVB/NJ MGP_FVBNJ_G0021774
 protein coding gene Chr15:71753926-71757443 (-)
LP/J MGP_LPJ_G0021864
 protein coding gene Chr15:76020269-76023786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021798
 protein coding gene Chr15:86594846-86598363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022389
 protein coding gene Chr15:75396331-75399848 (-)
PWK/PhJ MGP_PWKPhJ_G0020961
 protein coding gene Chr15:72839450-72842967 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020800
 protein coding gene Chr15:75126237-75129748 (-)
WSB/EiJ MGP_WSBEiJ_G0021272
 protein coding gene Chr15:75483638-75487155 (-)



Homology
more
  • Human Ortholog
    NAPRT, nicotinate phosphoribosyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAPRT, nicotinate phosphoribosyltransferase
  • Synonyms
    NAPRT1, PP3856
  • Links
    NCBI Gene ID: 93100
    neXtProt AC: NX_Q6XQN6
    UniProt: Q6XQN6

  • Chr Location
    8q24.3; chr8:143572874-143578649 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    36
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 223646 NCBI Gene Model | MGI Sequence Detail 3519 C57BL/6J ±  kb
transcript NM_172607 RefSeq | MGI Sequence Detail 1890 C57BL/6  
polypeptide Q8CC86 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010985 nicotinate phosphoribosyltransferase
    (term hierarchy)
  • EC
    6.3.4.21
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR041619 Nicotinate phosphoribosyltransferase C-terminal domain
    IPR007229 Nicotinate phosphoribosyltransferase family
    IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal
    IPR040727 Nicotinate phosphoribosyltransferase, N-terminal domain
    IPR006405 Nicotinate phosphoribosyltransferase pncB-type
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:352619 Membrez M, et al., Trigonelline is an NAD(+) precursor that improves muscle function during ageing and is reduced in human sarcopenia. Nat Metab. 2024 Mar;6(3):433-447
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory