Rfx7 MGI Mouse Gene Detail - MGI:2442675

Symbol

Rfx7
Name

regulatory factor X, 7
Synonyms

2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2

Feature Type

protein coding gene
IDs

MGI:2442675
NCBI Gene: 319758
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:72439522-72530111 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 40.08 cM
Mapping Data

1 experiment

SNPs within 2kb

1637 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442675	protein coding gene	Chr9:72439346-72530231 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035016	protein coding gene	Chr9:72699381-72790311 (+)
A/J	MGP_AJ_G0034997	protein coding gene	Chr9:70168500-70259998 (+)
AKR/J	MGP_AKRJ_G0034926	protein coding gene	Chr9:71843700-71937554 (+)
BALB/cJ	MGP_BALBcJ_G0034989	protein coding gene	Chr9:69875286-69965039 (+)
C3H/HeJ	MGP_C3HHeJ_G0034698	protein coding gene	Chr9:72346362-72440430 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035508	protein coding gene	Chr9:74597595-74694400 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032419	protein coding gene	Chr9:69661544-69754049 (+)
CAST/EiJ	MGP_CASTEiJ_G0034020	protein coding gene	Chr9:72657542-72750057 (+)
CBA/J	MGP_CBAJ_G0034671	protein coding gene	Chr9:77207401-77311654 (+)
DBA/2J	MGP_DBA2J_G0034830	protein coding gene	Chr9:69886222-69978368 (+)
FVB/NJ	MGP_FVBNJ_G0034772	protein coding gene	Chr9:69201838-69290499 (+)
LP/J	MGP_LPJ_G0034911	protein coding gene	Chr9:72901514-72997430 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034813	protein coding gene	Chr9:78292675-78404720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035530	protein coding gene	Chr9:71984486-72083251 (+)
PWK/PhJ	MGP_PWKPhJ_G0033724	protein coding gene	Chr9:70154068-70247439 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033557	protein coding gene	Chr9:72290825-72380884 (+)
WSB/EiJ	MGP_WSBEiJ_G0034132	protein coding gene	Chr9:71919118-72015640 (+)

Human Ortholog

RFX7, regulatory factor X7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RFX7, regulatory factor X7
Synonyms

MRD71, RFXDC2
Links

HGNC:25777

NCBI Gene ID: 64864

neXtProt AC: NX_Q2KHR2

UniProt: Q2KHR2
Chr Location

15q21.3; chr15:56087280-56245082 (-) GRCh38

MGI Vertebrate Homology

Rfx7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RFX7
Gene Tree

Rfx7

Diseases

1 with human RFX7 associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 3 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

21
Targeted

6
Genomic Mutations

1 involving Rfx7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit incomplete preweaning lethality. Mice homozygous for a null allele activated in hematopoietic cells exhibit decreased NK cell maintenance and immunity in vivo and increased NK cell size, granularity, proliferation, and energetic state.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

138
cDNA Data

109
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RFX7

Xenbase rfx7

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All Sequences

58
RefSeq

6
UniProt

6
CCDS

CCDS40686.1

Ensembl

ENSMUSG00000037674 (Evidence)
NCBI Gene

319758

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037674	Ensembl Gene Model \| MGI Sequence Detail	90590	C57BL/6J	± kb
transcript	ENSMUST00000163401	Ensembl \| MGI Sequence Detail	7880	Not Applicable
polypeptide	ENSMUSP00000127192	Ensembl \| MGI Sequence Detail	1459	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013929 DNA-binding protein RFX7

(term hierarchy)
InterPro Domains

IPR003150 DNA-binding RFX-type winged-helix domain

IPR039779 RFX-like DNA-binding protein

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 113

cDNA 109

Primer pair 2

Other 2

Microarray probesets 6

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MGI:1924254, MGI:2442903

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rfx7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86008	Chr9:72439010-72439039 (+)	-497 bp
Tssr86009	Chr9:72439215-72439232 (+)	-298 bp
Tssr86010	Chr9:72439466-72439489 (+)	-44 bp
Tssr86011	Chr9:72439496-72439553 (+)	3 bp
Tssr86012	Chr9:72440069-72440110 (+)	568 bp
Tssr2933	Chr9:72443692-72443696 (+)	4,172 bp
Tssr86013	Chr9:72445026-72445030 (+)	5,506 bp
Tssr86015	Chr9:72478077-72478091 (+)	38,562 bp
Tssr86016	Chr9:72488668-72488671 (+)	49,148 bp
Tssr86017	Chr9:72527727-72527729 (+)	88,206 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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