Slc30a8 MGI Mouse Gene Detail - MGI:2442682 - solute carrier family 30 (zinc transporter), member 8

Symbol

Slc30a8
Name

solute carrier family 30 (zinc transporter), member 8
Synonyms

C820002P14Rik, ZnT-8, ZnT8

Feature Type

protein coding gene
IDs

MGI:2442682
NCBI Gene: 239436
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:52158949-52199194 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 19.88 cM
Mapping Data

1 experiment

SNPs within 2kb

1287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442682	protein coding gene	Chr15:52158949-52199194 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021841	protein coding gene	Chr15:51269618-51314696 (+)
A/J	MGP_AJ_G0021801	protein coding gene	Chr15:49235779-49276961 (+)
AKR/J	MGP_AKRJ_G0021782	protein coding gene	Chr15:50618544-50658298 (+)
BALB/cJ	MGP_BALBcJ_G0021808	protein coding gene	Chr15:49483188-49524954 (+)
C3H/HeJ	MGP_C3HHeJ_G0021582	protein coding gene	Chr15:50725959-50773570 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022247	protein coding gene	Chr15:53288325-53334182 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019784	protein coding gene	Chr15:46262870-46301591 (+)
CAST/EiJ	MGP_CASTEiJ_G0021099	protein coding gene	Chr15:51278762-51319924 (+)
CBA/J	MGP_CBAJ_G0021551	protein coding gene	Chr15:55217862-55277655 (+)
DBA/2J	MGP_DBA2J_G0021675	protein coding gene	Chr15:49101471-49140655 (+)
FVB/NJ	MGP_FVBNJ_G0021653	protein coding gene	Chr15:48313643-48354351 (+)
LP/J	MGP_LPJ_G0021745	protein coding gene	Chr15:51069911-51114935 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021677	protein coding gene	Chr15:60214161-60259946 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022270	protein coding gene	Chr15:50966095-51008651 (+)
PWK/PhJ	MGP_PWKPhJ_G0020844	protein coding gene	Chr15:49191747-49233073 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020681	protein coding gene	Chr15:50708590-50751302 (+)
WSB/EiJ	MGP_WSBEiJ_G0021154	protein coding gene	Chr15:50966933-51005210 (+)

Human Ortholog

SLC30A8, solute carrier family 30 member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC30A8, solute carrier family 30 member 8
Synonyms

ZnT-8, ZNT8
Links

HGNC:20303

NCBI Gene ID: 169026

neXtProt AC: NX_Q8IWU4

UniProt: Q8IWU4
Chr Location

8q24.11; chr8:116950217-117176714 (+) GRCh38

MGI Vertebrate Homology

Slc30a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC30A8
Gene Tree

Slc30a8

Diseases

1 with human SLC30A8 associations

				Human Disease	Mouse Models
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 4 alleles in 4 genetic backgrounds
1 images
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

8
Genomic Mutations

3 involving Slc30a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion.

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All GO Annotations

45
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

10
Literature Summary

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc30a8

ZFIN slc30a8

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS27464.1

Ensembl

ENSMUSG00000022315 (Evidence)
NCBI Gene

239436

			Length	Strain/Species	Flank
genomic	239436	NCBI Gene Model \| MGI Sequence Detail	40246	C57BL/6J	± kb
transcript	NM_172816	RefSeq \| MGI Sequence Detail	1971	C57BL/6
polypeptide	Q8BGG0	UniProt \| EBI \| MGI Sequence Detail	367	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015081 proton-coupled zinc antiporter SLC30A8

(term hierarchy)
InterPro Domains

IPR050681 Cation Diffusion Facilitator/SLC30A

IPR002524 Cation efflux protein

IPR036837 Cation efflux protein, cytoplasmic domain superfamily

IPR027469 Cation efflux transmembrane domain superfamily

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 2

Summaries

All 76

Developmental Gene Expression 12

Diseases 1

Gene Ontology 12

Phenotypes 37
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc30a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131253	Chr15:52158905-52158941 (+)	-26 bp
Tssr131254	Chr15:52159038-52159050 (+)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24