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Creb3l2 Gene Detail
Summary
  • Symbol
    Creb3l2
  • Name
    cAMP responsive element binding protein 3-like 2
  • Synonyms
    BBF2H7, C530025K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442695
    NCBI Gene: 208647
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:37307956-37419083 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 16.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3470 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442695
 protein coding gene Chr6:37304190-37419083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030576
 protein coding gene Chr6:35534094-35657702 (-)
A/J MGP_AJ_G0030549
 protein coding gene Chr6:34019027-34137190 (-)
AKR/J MGP_AKRJ_G0030476
 protein coding gene Chr6:35108450-35231354 (-)
BALB/cJ MGP_BALBcJ_G0030559
 protein coding gene Chr6:34204766-34323879 (-)
C3H/HeJ MGP_C3HHeJ_G0030272
 protein coding gene Chr6:35112912-35233673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031013
 protein coding gene Chr6:36432568-36557934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028225
 protein coding gene Chr6:31931529-32048056 (-)
CAST/EiJ MGP_CASTEiJ_G0029674
 protein coding gene Chr6:34946990-35070936 (-)
CBA/J MGP_CBAJ_G0030250
 protein coding gene Chr6:37828162-37951673 (-)
DBA/2J MGP_DBA2J_G0030394
 protein coding gene Chr6:33858033-33967705 (-)
FVB/NJ MGP_FVBNJ_G0030348
 protein coding gene Chr6:33642287-33762833 (-)
LP/J MGP_LPJ_G0030481
 protein coding gene Chr6:35640278-35736564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030384
 protein coding gene Chr6:40226292-40364287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031043
 protein coding gene Chr6:35012014-35136902 (-)
PWK/PhJ MGP_PWKPhJ_G0029388
 protein coding gene Chr6:33484967-33603944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029224
 protein coding gene Chr6:34706760-34829350 (-)
WSB/EiJ MGP_WSBEiJ_G0029750
 protein coding gene Chr6:34960970-35083197 (-)



Homology
more
  • Human Ortholog
    CREB3L2, cAMP responsive element binding protein 3 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3L2, cAMP responsive element binding protein 3 like 2
  • Synonyms
    BBF2H7
  • Links
    NCBI Gene ID: 64764
    neXtProt AC: NX_Q70SY1
    UniProt: Q70SY1

  • Chr Location
    7q33; chr7:137874979-138002086 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe chondrodysplasia and die shortly after first birth from suffocation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    48
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208647 NCBI Gene Model | MGI Sequence Detail 111128 C57BL/6J ±  kb
    transcript NM_178661 RefSeq | MGI Sequence Detail 3318 C57BL/6  
    polypeptide Q8BH52 UniProt | EBI | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005857 cyclic AMP-responsive element-binding protein 3-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
    • GlyGen
      Q8BH52 4 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory