Slc22a19 Gene Detail

Summary

• Symbol
  Slc22a19
• Name
  solute carrier family 22 (organic anion transporter), member 19
• Synonyms
  D630043A20Rik, MGC:29260, Oat5, Slc22a9

• Feature Type
  protein coding gene
• IDs
  MGI:2442751
  NCBI Gene: 207151
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr19:7650440-7688675 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 5.34 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  655 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442751	protein coding gene	Chr19:7650426-7688675 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024797	protein coding gene	Chr19:4824994-4863683 (-)
A/J	MGP_AJ_G0024764	protein coding gene	Chr19:4481163-4518179 (-)
AKR/J	MGP_AKRJ_G0024737	protein coding gene	Chr19:4596135-4629977 (-)
BALB/cJ	MGP_BALBcJ_G0024764	protein coding gene	Chr19:4562621-4596963 (-)
C3H/HeJ	MGP_C3HHeJ_G0024531	protein coding gene	Chr19:4727691-4761948 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025210	protein coding gene	Chr19:4923395-4966332 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0024004	protein coding gene	Chr19:4639053-4678886 (-)
CBA/J	MGP_CBAJ_G0024504	protein coding gene	Chr19:4996936-5036471 (-)
DBA/2J	MGP_DBA2J_G0024631	protein coding gene	Chr19:4416882-4449026 (-)
FVB/NJ	MGP_FVBNJ_G0024596	protein coding gene	Chr19:4459151-4491724 (-)
LP/J	MGP_LPJ_G0024717	protein coding gene	Chr19:4667516-4717731 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024626	protein coding gene	Chr19:4899232-4940300 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025258	protein coding gene	Chr19:4760357-4795017 (-)
PWK/PhJ	MGP_PWKPhJ_G0023750	protein coding gene	Chr19:4486289-4520509 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023554	protein coding gene	Chr19:4553355-4585241 (-)
WSB/EiJ	MGP_WSBEiJ_G0024066	protein coding gene	Chr19:4652025-4688323 (-)

Homology

• Human Ortholog
  SLC22A10, solute carrier family 22 member 10

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SLC22A10, solute carrier family 22 member 10
  
• Synonyms
  hOAT5, OAT5
• Links
  HGNC:18057

  NCBI Gene ID: 387775

  neXtProt AC: NX_Q63ZE4

  UniProt: Q63ZE4

  
  
• Chr Location
  11q12.3

---

• Human Ortholog
  SLC22A24, solute carrier family 22 member 24
  
• Synonyms
  NET46
• Links
  HGNC:28542

  NCBI Gene ID: 283238

  neXtProt AC: NX_Q8N4F4

  UniProt: Q8N4F4

  
  
• Chr Location
  11q12.3; chr11:63079940-63144221 (-)  GRCh38

---

• Human Ortholog
  SLC22A25, solute carrier family 22 member 25
  
• Synonyms
  HIMTP, UST6
• Links
  HGNC:32935

  NCBI Gene ID: 387601

  neXtProt AC: NX_Q6T423

  UniProt: Q6T423

  
  
• Chr Location
  11q12.3; chr11:63158437-63243599 (-)  GRCh38

---

• Human Ortholog
  SLC22A9, solute carrier family 22 member 9
  
• Synonyms
  HOAT4, OAT4, OAT7, ust3, UST3H
• Links
  HGNC:16261

  NCBI Gene ID: 114571

  neXtProt AC: NX_Q8IVM8

  UniProt: Q8IVM8

  
  
• Chr Location
  11q12.3; chr11:63369785-63410294 (+)  GRCh38

---

• MGI Vertebrate Homology
  Slc22a19 stringent orthology
  4 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: SLC22A10, SLC22A24, SLC22A25, SLC22A9
• Gene Tree
  Slc22a19
  

Human Diseases

• Diseases
  2 with human SLC22A9 associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome       DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome       DOID:0112182 OMIM:276300 ORDO:252202

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  29 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  7

Expression

• Assay Results
  763
• Tissues
  56
• cDNA Data
  18
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  6
• UniProt
  1
• CCDS
  CCDS29532.1

• Ensembl
  ENSMUSG00000024757 (Evidence)
• NCBI Gene
  207151

Representative Sequences			Length	Strain/Species
genomic	207151	NCBI Gene Model | MGI Sequence Detail	38236	C57BL/6J
transcript	NM_144785	RefSeq | MGI Sequence Detail	1984	C57BL/6
polypeptide	Q8VCA0	UniProt | EBI | MGI Sequence Detail	551	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR005828 Major facilitator, sugar transporter-like
  IPR020846 Major facilitator superfamily domain
  IPR036259 MFS transporter superfamily
• GlyGen
  Q8VCA0 4 sites

Molecular
Reagents

• All nucleic 20

  cDNA 19

  Primer pair 1

  
  

  Microarray probesets 2

References

• Summaries
  All 29

  Developmental Gene Expression 4

  Gene Ontology 7

  Phenotypes 2
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc22a19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158001	Chr19:7688628-7688678 (-)	22 bp
Tssr158000	Chr19:7688600-7688611 (-)	69 bp
Tssr157999	Chr19:7688451-7688471 (-)	214 bp