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Tigar Gene Detail
Summary
  • Symbol
    Tigar
  • Name
    Trp53 induced glycolysis regulatory phosphatase
  • Synonyms
    9630033F20Rik, Tigar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442752
    NCBI Gene: 319801
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127062079-127086520 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    674 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442752
 protein coding gene Chr6:127062079-127086564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031312
 protein coding gene Chr6:130567126-130589489 (-)
A/J MGP_AJ_G0031283
 protein coding gene Chr6:125610594-125631730 (-)
AKR/J MGP_AKRJ_G0031211
 protein coding gene Chr6:129009171-129030215 (-)
BALB/cJ MGP_BALBcJ_G0031290
 protein coding gene Chr6:125168735-125188003 (-)
C3H/HeJ MGP_C3HHeJ_G0031014
 protein coding gene Chr6:129127273-129149557 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031747
 protein coding gene Chr6:133973316-133998573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028895
 protein coding gene Chr6:122784581-122804413 (-)
CAST/EiJ MGP_CASTEiJ_G0030395
 protein coding gene Chr6:129325365-129348213 (-)
CBA/J MGP_CBAJ_G0030975
 protein coding gene Chr6:139129345-139150916 (-)
DBA/2J MGP_DBA2J_G0031131
 protein coding gene Chr6:124497648-124518506 (-)
FVB/NJ MGP_FVBNJ_G0031080
 protein coding gene Chr6:123424945-123445098 (-)
LP/J MGP_LPJ_G0031211
 protein coding gene Chr6:130681987-130703455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031119
 protein coding gene Chr6:143085284-143104428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031782
 protein coding gene Chr6:128958656-128979545 (-)
PWK/PhJ MGP_PWKPhJ_G0030110
 protein coding gene Chr6:122769073-122789267 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029939
 protein coding gene Chr6:127041704-127061348 (-)
WSB/EiJ MGP_WSBEiJ_G0030480
 protein coding gene Chr6:129323352-129344114 (-)



Homology
more
  • Human Ortholog
    TIGAR, TP53 induced glycolysis regulatory phosphatase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIGAR, TP53 induced glycolysis regulatory phosphatase
  • Synonyms
    C12orf5, FR2BP
  • Links
    NCBI Gene ID: 57103
    neXtProt AC: NX_Q9NQ88
    UniProt: Q9NQ88

  • Chr Location
    12p13.32; chr12:4307763-4360028 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit improved response to myocardial infarction associated with increased autophagy, mitophagy, levels of reactive oxygen species production and decreased mitochondria DNA damage. Mice homozygous for a different allele exhibit impaired crypt regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    9
  • cDNA Data
    25
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038028 Ensembl Gene Model | MGI Sequence Detail 24442 C57BL/6J ±  kb
    transcript ENSMUST00000039913 Ensembl | MGI Sequence Detail 3651 Not Applicable  
    polypeptide ENSMUSP00000048643 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141452, MGI:2141756, MGI:3035180, MGI:3035247
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:32136 Forsthuber T, et al., Induction of TH1 and TH2 immunity in neonatal mice [see comments]. Science. 1996 Mar 22;271(5256):1728-30
    • Latest
      J:345711 He X, et al., TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice. Int J Mol Sci. 2024 Feb 19;25(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory