Smyd4 MGI Mouse Gene Detail - MGI:2442796 - SET and MYND domain containing 4

Symbol

Smyd4
Name

SET and MYND domain containing 4
Synonyms

G430029E23Rik

Feature Type

protein coding gene
IDs

MGI:2442796
NCBI Gene: 319822
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:75239259-75296531 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.82 cM
Mapping Data

1 experiment

SNPs within 2kb

1302 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442796	protein coding gene	Chr11:75239259-75296533 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018709	protein coding gene	Chr11:76093449-76149436 (+)
A/J	MGP_AJ_G0018675	protein coding gene	Chr11:73264149-73318436 (+)
AKR/J	MGP_AKRJ_G0018645	protein coding gene	Chr11:75479772-75533183 (+)
BALB/cJ	MGP_BALBcJ_G0018649	protein coding gene	Chr11:73633032-73689416 (+)
C3H/HeJ	MGP_C3HHeJ_G0018462	protein coding gene	Chr11:75493028-75550331 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019100	protein coding gene	Chr11:78465848-78527008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016735	protein coding gene	Chr11:70277257-70326870 (+)
CAST/EiJ	MGP_CASTEiJ_G0018016	protein coding gene	Chr11:75894920-75945079 (+)
CBA/J	MGP_CBAJ_G0018432	protein coding gene	Chr11:81902581-81963667 (+)
DBA/2J	MGP_DBA2J_G0018541	protein coding gene	Chr11:72873864-72925351 (+)
FVB/NJ	MGP_FVBNJ_G0018531	protein coding gene	Chr11:72435220-72484527 (+)
LP/J	MGP_LPJ_G0018612	protein coding gene	Chr11:76681057-76736329 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018557	protein coding gene	Chr11:82492747-82552141 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019140	protein coding gene	Chr11:75678193-75741516 (+)
PWK/PhJ	MGP_PWKPhJ_G0017787	protein coding gene	Chr11:73566307-73617006 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017578	protein coding gene	Chr11:75242539-75298962 (+)
WSB/EiJ	MGP_WSBEiJ_G0018069	protein coding gene	Chr11:75494912-75549128 (+)

Human Ortholog

SMYD4, SET and MYND domain containing 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SMYD4, SET and MYND domain containing 4
Synonyms

ZMYND21
Links

HGNC:21067

NCBI Gene ID: 114826

neXtProt AC: NX_Q8IYR2

UniProt: Q8IYR2
Chr Location

17p13.3; chr17:1779485-1830634 (-) GRCh38

MGI Vertebrate Homology

Smyd4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SMYD4
Gene Tree

Smyd4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

32
Targeted

4
Genomic Mutations

2 involving Smyd4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit testicular degeneration and atrophy.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

7
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase smyd4

ZFIN smyd4

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All Sequences

48
RefSeq

8
UniProt

1
CCDS

CCDS48848.1

Ensembl

ENSMUSG00000018809 (Evidence)
NCBI Gene

319822

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018809	Ensembl Gene Model \| MGI Sequence Detail	57273	C57BL/6J	± kb
transcript	ENSMUST00000044530	Ensembl \| MGI Sequence Detail	3517	Not Applicable
polypeptide	ENSMUSP00000047505	Ensembl \| MGI Sequence Detail	799	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032775 SET and MYND domain-containing protein 4

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR052097 SET and MYND domain-containing protein

IPR001214 SET domain

IPR046341 SET domain superfamily

IPR044421 SMYD4, SET domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR002893 Zinc finger, MYND-type

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 2

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Smyd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102937	Chr11:75239319-75239386 (+)	94 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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