Dhrs9 MGI Mouse Gene Detail - MGI:2442798 - dehydrogenase/reductase 9

Symbol

Dhrs9
Name

dehydrogenase/reductase 9
Synonyms

C730025I08Rik, dehydrogenase/reductase (SDR family) member 9, Rdh15

Feature Type

protein coding gene
IDs

MGI:2442798
NCBI Gene: 241452
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:69210806-69233430 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 40.59 cM
Mapping Data

1 experiment

SNPs within 2kb

800 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442798	protein coding gene	Chr2:69210789-69234877 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025798	protein coding gene	Chr2:69344347-69371780 (+)
A/J	MGP_AJ_G0025775	protein coding gene	Chr2:66666595-66690580 (+)
AKR/J	MGP_AKRJ_G0025744	protein coding gene	Chr2:68462629-68486525 (+)
BALB/cJ	MGP_BALBcJ_G0025770	protein coding gene	Chr2:66827712-66851668 (+)
C3H/HeJ	MGP_C3HHeJ_G0025530	protein coding gene	Chr2:68696284-68720134 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026217	protein coding gene	Chr2:71444951-71474178 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023620	protein coding gene	Chr2:63881356-63905371 (+)
CAST/EiJ	MGP_CASTEiJ_G0024994	protein coding gene	Chr2:68800083-68828607 (+)
CBA/J	MGP_CBAJ_G0025510	protein coding gene	Chr2:74052171-74081494 (+)
DBA/2J	MGP_DBA2J_G0025641	protein coding gene	Chr2:66304287-66328369 (+)
FVB/NJ	MGP_FVBNJ_G0025604	protein coding gene	Chr2:65678800-65702690 (+)
LP/J	MGP_LPJ_G0025730	protein coding gene	Chr2:69184766-69214343 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025633	protein coding gene	Chr2:76100204-76126432 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026274	protein coding gene	Chr2:68550836-68574728 (+)
PWK/PhJ	MGP_PWKPhJ_G0024735	protein coding gene	Chr2:66131787-66154845 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024542	protein coding gene	Chr2:68775816-68799660 (+)
WSB/EiJ	MGP_WSBEiJ_G0025062	protein coding gene	Chr2:68978243-69006468 (+)

Human Ortholog

DHRS9, dehydrogenase/reductase 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHRS9, dehydrogenase/reductase 9
Synonyms

3-alpha-HSD, 3ALPHA-HSD, hRoDH-E2, RDH15, RDHL, RDH-TBE, RDHTBE, RETSDR8, SDR9C4
Links

HGNC:16888

NCBI Gene ID: 10170

neXtProt AC: NX_Q9BPW9

UniProt: Q9BPW9
Chr Location

2q31.1; chr2:169064789-169096167 (+) GRCh38

MGI Vertebrate Homology

Dhrs9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHRS9
Gene Tree

Dhrs9

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Dhrs9
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null allele exhibit reduced LTB4 ad RvD1 dehydrogenase activities in the skin, lung, and tracheal microsomes.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

8
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dhrs9

ZFIN dhrs9

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS16091.1

Ensembl

ENSMUSG00000027068 (Evidence)
NCBI Gene

241452

			Length	Strain/Species	Flank
genomic	241452	NCBI Gene Model \| MGI Sequence Detail	22625	C57BL/6J	± kb
transcript	NM_175512	RefSeq \| MGI Sequence Detail	2817	C57BL/6
polypeptide	Q58NB6	UniProt \| EBI \| MGI Sequence Detail	319	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006470 dehydrogenase/reductase SDR family member 9

(term hierarchy)
EC

1.1.1.105, 1.1.1.209, 1.1.1.53
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dhrs9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18110	Chr2:69210775-69210802 (+)	-17 bp
Tssr18111	Chr2:69210812-69210822 (+)	11 bp
Tssr18112	Chr2:69210825-69210847 (+)	30 bp
Tssr18113	Chr2:69210877-69210886 (+)	76 bp
Tssr18114	Chr2:69212372-69212379 (+)	1,570 bp
Tssr18115	Chr2:69212394-69212401 (+)	1,592 bp
Tssr18116	Chr2:69212445-69212452 (+)	1,643 bp
Tssr18117	Chr2:69223330-69223339 (+)	12,529 bp
Tssr18118	Chr2:69223400-69223434 (+)	12,611 bp
Tssr18119	Chr2:69223446-69223519 (+)	12,677 bp
Tssr18120	Chr2:69224496-69224537 (+)	13,711 bp
Tssr18121	Chr2:69224553-69224601 (+)	13,771 bp
Tssr18122	Chr2:69224830-69224846 (+)	14,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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