Wdfy2 MGI Mouse Gene Detail - MGI:2442811 - WD repeat and FYVE domain containing 2

Symbol

Wdfy2
Name

WD repeat and FYVE domain containing 2
Synonyms

B130024L21Rik

Feature Type

protein coding gene
IDs

MGI:2442811
NCBI Gene: 268752
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr14:63075127-63198958 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.23 cM
Mapping Data

2 experiments

SNPs within 2kb

3422 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442811	protein coding gene	Chr14:63075110-63198958 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021450	protein coding gene	Chr14:57303692-57431155 (+)
A/J	MGP_AJ_G0021409	protein coding gene	Chr14:56014015-56140362 (+)
AKR/J	MGP_AKRJ_G0021385	protein coding gene	Chr14:58015893-58148632 (+)
BALB/cJ	MGP_BALBcJ_G0021415	protein coding gene	Chr14:55972022-56097316 (+)
C3H/HeJ	MGP_C3HHeJ_G0021192	protein coding gene	Chr14:57644437-57766781 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021854	protein coding gene	Chr14:60050351-60180654 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019394	protein coding gene	Chr14:53976526-54100344 (+)
CAST/EiJ	MGP_CASTEiJ_G0020709	protein coding gene	Chr14:54079675-54213922 (+)
CBA/J	MGP_CBAJ_G0021159	protein coding gene	Chr14:61786832-61934017 (+)
DBA/2J	MGP_DBA2J_G0021282	protein coding gene	Chr14:55680556-55800194 (+)
FVB/NJ	MGP_FVBNJ_G0021261	protein coding gene	Chr14:55094716-55222112 (+)
LP/J	MGP_LPJ_G0021357	protein coding gene	Chr14:58336524-58461956 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021290	protein coding gene	Chr14:61098154-61239159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021877	protein coding gene	Chr14:57158872-57285834 (+)
PWK/PhJ	MGP_PWKPhJ_G0020453	protein coding gene	Chr14:52361582-52486167 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020286	protein coding gene	Chr14:53132315-53268349 (+)
WSB/EiJ	MGP_WSBEiJ_G0020762	protein coding gene	Chr14:57476807-57611327 (+)

Human Ortholog

WDFY2, WD repeat and FYVE domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDFY2, WD repeat and FYVE domain containing 2
Synonyms

PROF, WDF2, ZFYVE22
Links

HGNC:20482

NCBI Gene ID: 115825

neXtProt AC: NX_Q96P53

UniProt: Q96P53
Chr Location

13q14.3; chr13:51584455-51767709 (+) GRCh38

MGI Vertebrate Homology

Wdfy2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDFY2
Gene Tree

Wdfy2

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

3
Targeted

4
Genomic Mutations

1 involving Wdfy2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit impaired glucose tolerance, insulin resistance, hepatic steatosis, increased gluconeogenesis and suppressed glycogen accumulation.

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

41
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WDFY2

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All Sequences

48
RefSeq

12
UniProt

1
CCDS

CCDS27192.1

Ensembl

ENSMUSG00000014547 (Evidence)
NCBI Gene

268752

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014547	Ensembl Gene Model \| MGI Sequence Detail	123832	C57BL/6J	± kb
transcript	ENSMUST00000014691	Ensembl \| MGI Sequence Detail	6646	Not Applicable
polypeptide	ENSMUSP00000014691	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030834 WD repeat and FYVE domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000306 FYVE zinc finger

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR042234 WD repeat and FYVE domain-containing protein 1/2

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 14

cDNA 14

Microarray probesets 1

Summaries

All 30

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:296933 Zhang L, et al., WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2. Diabetes. 2020 Sep;69(9):1887-1902

TSS for Wdfy2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126017	Chr14:63076075-63076126 (+)	974 bp
Tssr126018	Chr14:63094629-63094642 (+)	19,509 bp
Tssr126019	Chr14:63094871-63094887 (+)	19,752 bp
Tssr126020	Chr14:63094954-63094974 (+)	19,837 bp
Tssr126021	Chr14:63095010-63095043 (+)	19,900 bp
Tssr126022	Chr14:63096027-63096051 (+)	20,912 bp
Tssr126023	Chr14:63099962-63099966 (+)	24,837 bp
Tssr126026	Chr14:63119479-63119485 (+)	44,355 bp
Tssr126027	Chr14:63123999-63124029 (+)	48,887 bp
Tssr126028	Chr14:63124666-63124685 (+)	49,549 bp
Tssr126029	Chr14:63124699-63124714 (+)	49,580 bp
Tssr126030	Chr14:63131529-63131547 (+)	56,411 bp
Tssr126031	Chr14:63144306-63144344 (+)	69,198 bp
Tssr126032	Chr14:63155285-63155290 (+)	80,161 bp
Tssr126033	Chr14:63163893-63163905 (+)	88,772 bp
Tssr126034	Chr14:63172504-63172513 (+)	97,382 bp
Tssr126035	Chr14:63198129-63198157 (+)	123,016 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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