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Rigi Gene Detail
Summary
  • Symbol
    Rigi
  • Name
    RNA sensor RIG-I
  • Synonyms
    6430573D20Rik, Ddx58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442858
    NCBI Gene: 230073
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40203773-40239828 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1077 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442858
 protein coding gene Chr4:40203773-40239843 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028141
 protein coding gene Chr4:38046588-38093950 (-)
A/J MGP_AJ_G0028099
 protein coding gene Chr4:36646233-36682371 (-)
AKR/J MGP_AKRJ_G0028062
 protein coding gene Chr4:37526870-37567030 (-)
BALB/cJ MGP_BALBcJ_G0028111
 protein coding gene Chr4:36949323-36985902 (-)
C3H/HeJ MGP_C3HHeJ_G0027839
 protein coding gene Chr4:38109212-38147115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028552
 protein coding gene Chr4:39493978-39534578 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025893
 protein coding gene Chr4:34334204-34381186 (-)
CAST/EiJ MGP_CASTEiJ_G0027295
 protein coding gene Chr4:37774118-37817845 (-)
CBA/J MGP_CBAJ_G0027811
 protein coding gene Chr4:40828570-40864941 (-)
DBA/2J MGP_DBA2J_G0027955
 protein coding gene Chr4:36558520-36593859 (-)
FVB/NJ MGP_FVBNJ_G0027922
 protein coding gene Chr4:35905810-35943248 (-)
LP/J MGP_LPJ_G0028063
 protein coding gene Chr4:38121554-38162508 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027955
 protein coding gene Chr4:44193757-44233206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028611
 protein coding gene Chr4:37659329-37700714 (-)
PWK/PhJ MGP_PWKPhJ_G0027013
 protein coding gene Chr4:36537323-36580777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026842
 protein coding gene Chr4:37386957-37432284 (-)
WSB/EiJ MGP_WSBEiJ_G0027371
 protein coding gene Chr4:37659431-37696407 (-)



Homology
more
  • Human Ortholog
    RIGI, RNA sensor RIG-I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIGI, RNA sensor RIG-I
  • Synonyms
    DDX58, RIG1, RIG-I, RLR-1, SGMRT2
  • Links
    NCBI Gene ID: 23586
    neXtProt AC: NX_O95786
    UniProt: O95786

  • Chr Location
    9p21.1; chr9:32455302-32526348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygotes for a null allele die in utero with liver apoptosis while survivors show impaired IFN induction and succumb to infection with certain RNA viruses. Homozygotes for another null allele are viable but develop colitis and progressive granulocytosis leading to chronic myeloid leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    13
  • cDNA Data
    53
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040296 Ensembl Gene Model | MGI Sequence Detail 36056 C57BL/6J ±  kb
    transcript ENSMUST00000037907 Ensembl | MGI Sequence Detail 3874 Not Applicable  
    polypeptide ENSMUSP00000042433 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 53
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:7328921
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 5
      Gene Ontology 16
      Phenotypes 71
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353283 Yermalovich AV, et al., An essential role for Cmtr2 in mammalian embryonic development. Dev Biol. 2024 Jul 31;516:47-58
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory