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Eda2r Gene Detail
Summary
  • Symbol
    Eda2r
  • Name
    ectodysplasin A2 receptor
  • Synonyms
    9430060M22Rik, Xedar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442860
    NCBI Gene: 245527
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:96377446-96420822 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    849 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442860
 protein coding gene ChrX:96375936-96420822 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035930
 protein coding gene ChrX:93728326-93770469 (-)
A/J MGP_AJ_G0035915
 protein coding gene ChrX:93865071-93916199 (-)
AKR/J MGP_AKRJ_G0035831
 protein coding gene ChrX:96455875-96505815 (-)
BALB/cJ MGP_BALBcJ_G0035898
 protein coding gene ChrX:92613719-92656904 (-)
C3H/HeJ MGP_C3HHeJ_G0035607
 protein coding gene ChrX:94193695-94239267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036427
 protein coding gene ChrX:96648698-96693481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033257
 protein coding gene ChrX:91726706-91769301 (-)
CAST/EiJ MGP_CASTEiJ_G0034894
 protein coding gene ChrX:78595194-78653117 (-)
CBA/J MGP_CBAJ_G0035582
 protein coding gene ChrX:99586374-99640444 (-)
DBA/2J MGP_DBA2J_G0035736
 protein coding gene ChrX:93087388-93133095 (-)
FVB/NJ MGP_FVBNJ_G0035674
 protein coding gene ChrX:92477623-92520425 (-)
LP/J MGP_LPJ_G0035826
 protein coding gene ChrX:94690617-94734771 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035709
 protein coding gene ChrX:103957714-104009412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036454
 protein coding gene ChrX:93448017-93492640 (-)
PWK/PhJ MGP_PWKPhJ_G0034593
 protein coding gene ChrX:76272581-76312086 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034421
 protein coding gene ChrX:79462983-79505162 (-)
WSB/EiJ MGP_WSBEiJ_G0035033
 protein coding gene ChrX:92232660-92278994 (-)



Homology
more
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
  • Synonyms
    EDA-A2R, EDAA2R, TNFRSF27, XEDAR
  • Links
    NCBI Gene ID: 60401
    neXtProt AC: NX_Q9HAV5
    UniProt: Q9HAV5

  • Chr Location
    Xq12; chrX:66595637-66639298 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Hemizygous null males are fertile and healthy with no histological abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    24
  • cDNA Data
    18
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034457 Ensembl Gene Model | MGI Sequence Detail 43377 C57BL/6J ±  kb
transcript ENSMUST00000037353 Ensembl | MGI Sequence Detail 4752 Not Applicable  
polypeptide ENSMUSP00000041210 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006887 tumor necrosis factor receptor superfamily member 27
    (term hierarchy)
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR034060 Tumor necrosis factor receptor 27, N-terminal
    IPR047526 Tumor necrosis factor receptor superfamily member 19/27/EDAR
    IPR022319 Tumour necrosis factor receptor 27
  • GlyGen
    Q8BX35 2 sites
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:77350 Naito A, et al., TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8766-71
  • Latest
    J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory