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Tmprss11b Gene Detail
Summary
  • Symbol
    Tmprss11b
  • Name
    transmembrane protease, serine 11B
  • Synonyms
    9930019B18Rik, Tmprss11bnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442893
    NCBI Gene: 319875
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86806326-86824221 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    666 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442893
 protein coding gene Chr5:86805490-86824221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029672
 protein coding gene Chr5:87507894-87528292 (-)
A/J MGP_AJ_G0029640
 protein coding gene Chr5:83924947-83943775 (-)
AKR/J MGP_AKRJ_G0029588
 protein coding gene Chr5:86716512-86736534 (-)
BALB/cJ MGP_BALBcJ_G0029649
 protein coding gene Chr5:84841519-84860097 (-)
C3H/HeJ MGP_C3HHeJ_G0029372
 protein coding gene Chr5:87182139-87200542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030103
 protein coding gene Chr5:91108097-91126848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027345
 protein coding gene Chr5:79722570-79741443 (-)
CAST/EiJ MGP_CASTEiJ_G0028780
 protein coding gene Chr5:86475524-86495866 (-)
CBA/J MGP_CBAJ_G0029341
 protein coding gene Chr5:94038123-94058646 (-)
DBA/2J MGP_DBA2J_G0029486
 protein coding gene Chr5:84112582-84130936 (-)
FVB/NJ MGP_FVBNJ_G0029447
 protein coding gene Chr5:83039131-83057341 (-)
LP/J MGP_LPJ_G0029573
 protein coding gene Chr5:87908203-87935145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029475
 protein coding gene Chr5:98923734-98945159 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030136
 protein coding gene Chr5:86272524-86291109 (-)
PWK/PhJ MGP_PWKPhJ_G0028504
 protein coding gene Chr5:83071531-83090622 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028337
 protein coding gene Chr5:85635878-85656383 (-)
WSB/EiJ MGP_WSBEiJ_G0028861
 protein coding gene Chr5:86658255-86676435 (-)



Homology
more
  • Human Ortholog
    TMPRSS11B, transmembrane serine protease 11B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS11B, transmembrane serine protease 11B
  • Synonyms
    HATL5
  • Links
    NCBI Gene ID: 132724
    neXtProt AC: NX_Q86T26
    UniProt: Q86T26

  • Chr Location
    4q13.2; chr4:68226653-68245694 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 319875 NCBI Gene Model | MGI Sequence Detail 17896 C57BL/6J ±  kb
transcript NM_177024 RefSeq | MGI Sequence Detail 3335 C57BL/6  
polypeptide Q14C59 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory