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Rab8b Gene Detail
Summary
  • Symbol
    Rab8b
  • Name
    RAB8B, member RAS oncogene family
  • Synonyms
    D330025I23Rik, Rab8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442982
    NCBI Gene: 235442
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66750946-66826969 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 36.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1652 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442982
 protein coding gene Chr9:66750891-66826987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034982
 protein coding gene Chr9:66723308-66798802 (-)
A/J MGP_AJ_G0034962
 protein coding gene Chr9:64407871-64486146 (-)
AKR/J MGP_AKRJ_G0034892
 protein coding gene Chr9:65944055-66021783 (-)
BALB/cJ MGP_BALBcJ_G0034955
 protein coding gene Chr9:64140647-64217837 (-)
C3H/HeJ MGP_C3HHeJ_G0034664
 protein coding gene Chr9:66477983-66558008 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035474
 protein coding gene Chr9:68542257-68622086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032385
 protein coding gene Chr9:64041179-64116494 (-)
CAST/EiJ MGP_CASTEiJ_G0033986
 protein coding gene Chr9:66705871-66787735 (-)
CBA/J MGP_CBAJ_G0034636
 protein coding gene Chr9:70887783-70972380 (-)
DBA/2J MGP_DBA2J_G0034795
 protein coding gene Chr9:64179387-64254450 (-)
FVB/NJ MGP_FVBNJ_G0034737
 protein coding gene Chr9:63520733-63598176 (-)
LP/J MGP_LPJ_G0034877
 protein coding gene Chr9:66993826-67074538 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034779
 protein coding gene Chr9:72116309-72198964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035496
 protein coding gene Chr9:66058559-66141336 (-)
PWK/PhJ MGP_PWKPhJ_G0033690
 protein coding gene Chr9:64406887-64483485 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033523
 protein coding gene Chr9:66372879-66450127 (-)
WSB/EiJ MGP_WSBEiJ_G0034098
 protein coding gene Chr9:65958338-66035575 (-)



Homology
more
  • Human Ortholog
    RAB8B, RAB8B, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB8B, RAB8B, member RAS oncogene family
  • Links
    NCBI Gene ID: 51762
    neXtProt AC: NX_Q92930
    UniProt: Q92930

  • Chr Location
    15q22.2; chr15:63189560-63267776 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele exhibit no overt abnormalities and normal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    88
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036943 Ensembl Gene Model | MGI Sequence Detail 76024 C57BL/6J ±  kb
transcript ENSMUST00000041139 Ensembl | MGI Sequence Detail 4733 Not Applicable  
polypeptide ENSMUSP00000041857 Ensembl | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013643 Ras-related protein Rab-8B
    (term hierarchy)
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase
    IPR050305 Small GTPase superfamily, Rab
    IPR005225 Small GTP-binding protein domain
  • GlyGen
    P61028 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 89
    cDNA 88
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:340074 Wu J, et al., EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Blood Adv. 2023 Jul 25;7(14):3382-3394
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory