Lman2l MGI Mouse Gene Detail - MGI:2443010 - lectin, mannose-binding 2-like

Symbol

Lman2l
Name

lectin, mannose-binding 2-like
Synonyms

A630028F14Rik, VIP36-like

Feature Type

protein coding gene
IDs

MGI:2443010
NCBI Gene: 214895
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:36458952-36484352 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.26 cM
Mapping Data

1 experiment

SNPs within 2kb

658 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443010	protein coding gene	Chr1:36458274-36484352 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015923	protein coding gene	Chr1:34949118-34974516 (-)
A/J	MGP_AJ_G0015907	protein coding gene	Chr1:34014228-34039843 (-)
AKR/J	MGP_AKRJ_G0015862	protein coding gene	Chr1:34499250-34525987 (-)
BALB/cJ	MGP_BALBcJ_G0015861	protein coding gene	Chr1:33705986-33731952 (-)
C3H/HeJ	MGP_C3HHeJ_G0015694	protein coding gene	Chr1:34686443-34712932 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016314	protein coding gene	Chr1:36538390-36565407 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014036	protein coding gene	Chr1:31068794-31093508 (-)
CAST/EiJ	MGP_CASTEiJ_G0015275	protein coding gene	Chr1:34575683-34601041 (-)
CBA/J	MGP_CBAJ_G0015666	protein coding gene	Chr1:37488478-37516639 (-)
DBA/2J	MGP_DBA2J_G0015767	protein coding gene	Chr1:33350990-33377194 (-)
FVB/NJ	MGP_FVBNJ_G0015769	protein coding gene	Chr1:32869338-32895836 (-)
LP/J	MGP_LPJ_G0015837	protein coding gene	Chr1:35314364-35339768 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015789	protein coding gene	Chr1:39720284-39746725 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016361	protein coding gene	Chr1:34523664-34555503 (-)
PWK/PhJ	MGP_PWKPhJ_G0015058	protein coding gene	Chr1:33098453-33124387 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014840	protein coding gene	Chr1:34477174-34503018 (-)
WSB/EiJ	MGP_WSBEiJ_G0015337	protein coding gene	Chr1:34476566-34502954 (-)

Human Ortholog

LMAN2L, lectin, mannose binding 2 like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMAN2L, lectin, mannose binding 2 like
Synonyms

MRD69, MRT52, VIPL
Links

HGNC:19263

NCBI Gene ID: 81562

neXtProt AC: NX_Q9H0V9

UniProt: Q9H0V9
Chr Location

2q11.2; chr2:96705929-96740064 (-) GRCh38

MGI Vertebrate Homology

Lman2l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LMAN2L
Gene Tree

Lman2l

Diseases

2 with human LMAN2L associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469
				autosomal recessive intellectual developmental disorder 52 IDs autosomal recessive intellectual developmental disorder 52 DOID:0081215 OMIM:616887

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Genomic Mutations

1 involving Lman2l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

65

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lman2l

ZFIN lman2la, lman2lb

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All Sequences

66
RefSeq

12
UniProt

7
CCDS

CCDS14878.1, CCDS78563.1

Ensembl

ENSMUSG00000001143 (Evidence)
NCBI Gene

214895

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001143	Ensembl Gene Model \| MGI Sequence Detail	25401	C57BL/6J	± kb
transcript	ENSMUST00000115011	Ensembl \| MGI Sequence Detail	2290	Not Applicable
polypeptide	ENSMUSP00000110663	Ensembl \| MGI Sequence Detail	358	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009853 VIP36-like protein

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR051136 Intracellular Lectin and Glycoprotein Transporter

IPR005052 Legume-like lectin
GlyGen

P59481 2 sites, 8 N-linked glycans (2 sites)

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All nucleic 65

cDNA 65

Microarray probesets 4

Summaries

All 32

Gene Ontology 5

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563

TSS for Lman2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11258	Chr1:36484329-36484345 (-)	15 bp
Tssr11257	Chr1:36484312-36484323 (-)	34 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24