Dnajc27 MGI Mouse Gene Detail - MGI:2443036 - DnaJ heat shock protein family (Hsp40) member C27

Symbol

Dnajc27
Name

DnaJ heat shock protein family (Hsp40) member C27
Synonyms

C330021A05Rik, Rabj, Rbj

Feature Type

protein coding gene
IDs

MGI:2443036
NCBI Gene: 217378
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:4132583-4160606 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 1.99 cM
Mapping Data

2 experiments

SNPs within 2kb

789 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443036	protein coding gene	Chr12:4132569-4174140 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019563	protein coding gene	Chr12:941021-968999 (+)
A/J	MGP_AJ_G0019530	protein coding gene	Chr12:961525-993648 (+)
AKR/J	MGP_AKRJ_G0019500	protein coding gene	Chr12:1114669-1144723 (+)
BALB/cJ	MGP_BALBcJ_G0019505	protein coding gene	Chr12:989160-1017394 (+)
C3H/HeJ	MGP_C3HHeJ_G0019311	protein coding gene	Chr12:892327-924944 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019954	protein coding gene	Chr12:960282-990311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017579	protein coding gene	Chr12:869892-902299 (+)
CAST/EiJ	MGP_CASTEiJ_G0018866	protein coding gene	Chr12:966964-998633 (+)
CBA/J	MGP_CBAJ_G0019282	protein coding gene	Chr12:1211264-1242233 (+)
DBA/2J	MGP_DBA2J_G0019395	protein coding gene	Chr12:903320-931927 (+)
FVB/NJ	MGP_FVBNJ_G0019385	protein coding gene	Chr12:927997-957154 (+)
LP/J	MGP_LPJ_G0019466	protein coding gene	Chr12:959969-992082 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019419	protein coding gene	Chr12:1018278-1048651 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019993	protein coding gene	Chr12:896509-926532 (+)
PWK/PhJ	MGP_PWKPhJ_G0018632	protein coding gene	Chr12:925581-954301 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018423	protein coding gene	Chr12:966484-996547 (+)
WSB/EiJ	MGP_WSBEiJ_G0018918	protein coding gene	Chr12:924808-952817 (+)

Human Ortholog

DNAJC27, DnaJ heat shock protein family (Hsp40) member C27

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC27, DnaJ heat shock protein family (Hsp40) member C27
Synonyms

RabJS, RBJ
Links

HGNC:30290

NCBI Gene ID: 51277

neXtProt AC: NX_Q9NZQ0

UniProt: Q9NZQ0
Chr Location

2p23.3; chr2:24943636-24972094 (-) GRCh38

MGI Vertebrate Homology

Dnajc27 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC27
Gene Tree

Dnajc27

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit decreased incidence, multiplicity and tumor burden in an AOM/DSS-induced colonic carcinogenesis model.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

66

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc27

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All Sequences

58
RefSeq

17
UniProt

1
CCDS

CCDS25786.1

Ensembl

ENSMUSG00000020657 (Evidence)
NCBI Gene

217378

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020657	Ensembl Gene Model \| MGI Sequence Detail	28024	C57BL/6J	± kb
transcript	ENSMUST00000020986	Ensembl \| MGI Sequence Detail	4698	Not Applicable
polypeptide	ENSMUSP00000020986	Ensembl \| MGI Sequence Detail	273	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031986 DnaJ homolog subfamily C member 27

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 66

cDNA 66

Microarray probesets 3

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MGI:2144867

Summaries

All 30

Gene Ontology 4

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajc27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112543	Chr12:4132575-4132594 (+)	2 bp
Tssr112544	Chr12:4132596-4132638 (+)	34 bp
Tssr112545	Chr12:4132641-4132652 (+)	64 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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