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Ttll1 Gene Detail
Summary
  • Symbol
    Ttll1
  • Name
    tubulin tyrosine ligase-like 1
  • Synonyms
    6330444E16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443047
    NCBI Gene: 319953
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83367970-83395094 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    915 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443047
 protein coding gene Chr15:83367258-83402675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022164
 protein coding gene Chr15:84189339-84216758 (-)
A/J MGP_AJ_G0022123
 protein coding gene Chr15:81108923-81135205 (-)
AKR/J MGP_AKRJ_G0022098
 protein coding gene Chr15:83463533-83497180 (-)
BALB/cJ MGP_BALBcJ_G0022129
 protein coding gene Chr15:81250539-81277799 (-)
C3H/HeJ MGP_C3HHeJ_G0021899
 protein coding gene Chr15:83426455-83454827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022574
 protein coding gene Chr15:87438613-87467727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020099
 protein coding gene Chr15:77483552-77510350 (-)
CAST/EiJ MGP_CASTEiJ_G0021421
 protein coding gene Chr15:84190878-84224122 (-)
CBA/J MGP_CBAJ_G0021866
 protein coding gene Chr15:90203316-90234000 (-)
DBA/2J MGP_DBA2J_G0021993
 protein coding gene Chr15:80591353-80618302 (-)
FVB/NJ MGP_FVBNJ_G0021972
 protein coding gene Chr15:79636276-79663255 (-)
LP/J MGP_LPJ_G0022064
 protein coding gene Chr15:84364505-84391043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021992
 protein coding gene Chr15:95102888-95135957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022589
 protein coding gene Chr15:83468911-83497901 (-)
PWK/PhJ MGP_PWKPhJ_G0021162
 protein coding gene Chr15:80573123-80604364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020996
 protein coding gene Chr15:83203421-83229016 (-)
WSB/EiJ MGP_WSBEiJ_G0021470
 protein coding gene Chr15:83967817-84000250 (-)



Homology
more
  • Human Ortholog
    TTLL1, TTL family tubulin polyglutamylase complex subunit L1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTLL1, TTL family tubulin polyglutamylase complex subunit L1
  • Synonyms
    C22orf7, HS323M22B, TPGS3
  • Links
    NCBI Gene ID: 25809
    neXtProt AC: NX_O95922
    UniProt: O95922

  • Chr Location
    22q13.2; chr22:43039516-43089419 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ttll1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit short sperm flagella, abnormal tracheal cilia morphology and function, abnormal mucociliary clearance, and rhinosinusitis with coughing and sneezing-like noises. Brain lysates show a significant reduction in polyglutamylated alpha-tubulins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    38
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022442 Ensembl Gene Model | MGI Sequence Detail 27125 C57BL/6J ±  kb
    transcript ENSMUST00000016897 Ensembl | MGI Sequence Detail 2060 Not Applicable  
    polypeptide ENSMUSP00000016897 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 38
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146161
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory