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Trpm3 Gene Detail
Summary
  • Symbol
    Trpm3
  • Name
    transient receptor potential cation channel, subfamily M, member 3
  • Synonyms
    6330504P12Rik, B930001P07Rik, LTRPC3, melastatin 2, MLSN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443101
    NCBI Gene: 226025
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:22116410-22972774 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 16.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443101
 protein coding gene Chr19:22114789-22972774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024982
 protein coding gene Chr19:20209495-21090649 (+)
A/J MGP_AJ_G0024959
 protein coding gene Chr19:19103731-19950910 (+)
AKR/J MGP_AKRJ_G0024929
 protein coding gene Chr19:19832481-20704680 (+)
BALB/cJ MGP_BALBcJ_G0024958
 protein coding gene Chr19:19142066-19987887 (+)
C3H/HeJ MGP_C3HHeJ_G0024716
 protein coding gene Chr19:19792549-20666787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025400
 protein coding gene Chr19:20887095-21789148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022819
 protein coding gene Chr19:19300245-20137321 (+)
CAST/EiJ MGP_CASTEiJ_G0024184
 protein coding gene Chr19:19475621-20368832 (+)
CBA/J MGP_CBAJ_G0024694
 protein coding gene Chr19:21724844-22689093 (+)
DBA/2J MGP_DBA2J_G0024826
 protein coding gene Chr19:19107153-19962184 (+)
FVB/NJ MGP_FVBNJ_G0024787
 protein coding gene Chr19:18986078-19819937 (+)
LP/J MGP_LPJ_G0024910
 protein coding gene Chr19:20158706-21033657 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024814
 protein coding gene Chr19:21866136-22796291 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025455
 protein coding gene Chr19:19765069-20676300 (+)
PWK/PhJ MGP_PWKPhJ_G0023933
 protein coding gene Chr19:18672850-19526914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023738
 protein coding gene Chr19:19053568-19920078 (+)
WSB/EiJ MGP_WSBEiJ_G0024252
 protein coding gene Chr19:19849181-20719141 (+)



Homology
more
  • Human Ortholog
    TRPM3, transient receptor potential cation channel subfamily M member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM3, transient receptor potential cation channel subfamily M member 3
  • Synonyms
    CTRCT50, GON-2, LTRPC3, MLSN2, NEDFSS
  • Links
    NCBI Gene ID: 80036
    neXtProt AC: NX_Q9HCF6
    UniProt: Q9HCF6

  • Chr Location
    9q21.12-q21.13; chr9:70529060-71446977 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Trpm3 mouse models; 1 with human TRPM3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to impaired thermal and chemical nociception. Homozygous KO also results in small eyes and lenses, while a specific point mutation additionally leads to cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    78
  • cDNA Data
    25
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052387 Ensembl Gene Model | MGI Sequence Detail 856365 C57BL/6J ±  kb
    transcript ENSMUST00000235522 Ensembl | MGI Sequence Detail 5320 Not Applicable  
    polypeptide ENSMUSP00000158045 Ensembl | MGI Sequence Detail 1731 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 30
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147643, MGI:2662432
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 2
      Phenotypes 28
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:354852 Singh K, et al., The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024 Sep 30;14(1):22593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory