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Abcc4 Gene Detail
Summary
  • Symbol
    Abcc4
  • Name
    ATP-binding cassette, sub-family C member 4
  • Synonyms
    D630049P08Rik, MOAT-B, MRP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443111
    NCBI Gene: 239273
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118720104-118943631 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 62.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7903 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443111
 protein coding gene Chr14:118720104-118945475 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021650
 protein coding gene Chr14:116085673-116316023 (-)
A/J MGP_AJ_G0021610
 protein coding gene Chr14:111645672-111879923 (-)
AKR/J MGP_AKRJ_G0021586
 protein coding gene Chr14:115265659-115498506 (-)
BALB/cJ MGP_BALBcJ_G0021616
 protein coding gene Chr14:112185551-112416802 (-)
C3H/HeJ MGP_C3HHeJ_G0021394
 protein coding gene Chr14:115140871-115390043 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022056
 protein coding gene Chr14:120574583-120826573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019594
 protein coding gene Chr14:107702627-107915020 (-)
CAST/EiJ MGP_CASTEiJ_G0020909
 protein coding gene Chr14:112985585-113225029 (-)
CBA/J MGP_CBAJ_G0021362
 protein coding gene Chr14:125193907-125455500 (-)
DBA/2J MGP_DBA2J_G0021485
 protein coding gene Chr14:111563451-111788938 (-)
FVB/NJ MGP_FVBNJ_G0021463
 protein coding gene Chr14:109896212-110118270 (-)
LP/J MGP_LPJ_G0021553
 protein coding gene Chr14:117103812-117346909 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021490
 protein coding gene Chr14:130267329-130512542 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022079
 protein coding gene Chr14:114750259-114984227 (-)
PWK/PhJ MGP_PWKPhJ_G0020653
 protein coding gene Chr14:108560415-108792328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020491
 protein coding gene Chr14:110986320-111229124 (-)
WSB/EiJ MGP_WSBEiJ_G0020965
 protein coding gene Chr14:115531259-115765499 (-)



Homology
more
  • Human Ortholog
    ABCC4, ATP binding cassette subfamily C member 4 (PEL blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCC4, ATP binding cassette subfamily C member 4 (PEL blood group)
  • Synonyms
    MOAT-B, MOATB, MRP4
  • Links
    NCBI Gene ID: 10257
    neXtProt AC: NX_O15439
    UniProt: O15439

  • Chr Location
    13q32.1; chr13:95019835-95301475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    149
  • cDNA Data
    7
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032849 Ensembl Gene Model | MGI Sequence Detail 223528 C57BL/6J ±  kb
    transcript ENSMUST00000036554 Ensembl | MGI Sequence Detail 5715 Not Applicable  
    polypeptide ENSMUSP00000042186 Ensembl | MGI Sequence Detail 1325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003560 ATP-binding cassette sub-family C member 4
      (term hierarchy)
    • EC
      7.6.2.-, 7.6.2.2, 7.6.2.3
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR030240 ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 1
      IPR047083 ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 2
      IPR050173 ATP-binding cassette transporter C
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      E9Q236 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 40
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory