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Wdr3 Gene Detail
Summary
  • Symbol
    Wdr3
  • Name
    WD repeat domain 3
  • Synonyms
    D030020G18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443143
    NCBI Gene: 269470
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100045496-100069723 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    748 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443143
 protein coding gene Chr3:100045496-100069723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027665
 protein coding gene Chr3:101257944-101283147 (-)
A/J MGP_AJ_G0027624
 protein coding gene Chr3:98037270-98063876 (-)
AKR/J MGP_AKRJ_G0027590
 protein coding gene Chr3:100414775-100438843 (-)
BALB/cJ MGP_BALBcJ_G0027637
 protein coding gene Chr3:97817255-97841524 (-)
C3H/HeJ MGP_C3HHeJ_G0027366
 protein coding gene Chr3:100732392-100757545 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028080
 protein coding gene Chr3:104975522-105002613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025421
 protein coding gene Chr3:94265644-94290115 (-)
CAST/EiJ MGP_CASTEiJ_G0026822
 protein coding gene Chr3:99847362-99873339 (-)
CBA/J MGP_CBAJ_G0027341
 protein coding gene Chr3:108598293-108622829 (-)
DBA/2J MGP_DBA2J_G0027484
 protein coding gene Chr3:97288734-97312782 (-)
FVB/NJ MGP_FVBNJ_G0027452
 protein coding gene Chr3:95240476-95266259 (-)
LP/J MGP_LPJ_G0027591
 protein coding gene Chr3:102596995-102621049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027482
 protein coding gene Chr3:114807383-114878327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028135
 protein coding gene Chr3:99918253-99943298 (-)
PWK/PhJ MGP_PWKPhJ_G0026549
 protein coding gene Chr3:97044514-97068973 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026371
 protein coding gene Chr3:98039988-98063920 (-)
WSB/EiJ MGP_WSBEiJ_G0026902
 protein coding gene Chr3:100496955-100523108 (-)



Homology
more
  • Human Ortholog
    WDR3, WD repeat domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR3, WD repeat domain 3
  • Synonyms
    DIP2, UTP12
  • Links
    NCBI Gene ID: 10885
    neXtProt AC: NX_Q9UNX4
    UniProt: Q9UNX4

  • Chr Location
    1p12; chr1:117929720-117966543 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WDR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete prenatal lethality. Heterozygotes show normal growth and brain anatomy but exhibit a slight but significant increase in spontaneous locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 269470 NCBI Gene Model | MGI Sequence Detail 24228 C57BL/6J ±  kb
transcript NM_175552 RefSeq | MGI Sequence Detail 3444 C57BL/6  
polypeptide Q8BHB4 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029860 WD repeat-containing protein 3
    (term hierarchy)
  • InterPro Domains
    IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain
    IPR020472 G-protein beta WD-40 repeat
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR007148 Small-subunit processome, Utp12
    IPR051570 TBC1 domain family involved in cilium biogenesis
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q8BHB4 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139997
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory