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Pag1 Gene Detail
Summary
  • Symbol
    Pag1
  • Name
    phosphoprotein associated with glycosphingolipid microdomains 1
  • Synonyms
    Cbp, F730007C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443160
    NCBI Gene: 94212
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:9752539-9898739 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.47 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4297 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443160
 protein coding gene Chr3:9752539-9898744 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027058
 protein coding gene Chr3:6612874-6766399 (-)
A/J MGP_AJ_G0027022
 protein coding gene Chr3:6794210-6938669 (-)
AKR/J MGP_AKRJ_G0026992
 protein coding gene Chr3:6690216-6838440 (-)
BALB/cJ MGP_BALBcJ_G0027031
 protein coding gene Chr3:6519833-6669899 (-)
C3H/HeJ MGP_C3HHeJ_G0026771
 protein coding gene Chr3:6990628-7145986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027475
 protein coding gene Chr3:7249362-7405779 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024837
 protein coding gene Chr3:5740948-5883525 (-)
CAST/EiJ MGP_CASTEiJ_G0026229
 protein coding gene Chr3:7024465-7182656 (-)
CBA/J MGP_CBAJ_G0026749
 protein coding gene Chr3:7208898-7375642 (-)
DBA/2J MGP_DBA2J_G0026885
 protein coding gene Chr3:6371678-6517450 (-)
FVB/NJ MGP_FVBNJ_G0026852
 protein coding gene Chr3:6301361-6442924 (-)
LP/J MGP_LPJ_G0026995
 protein coding gene Chr3:7144529-7293818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026872
 protein coding gene Chr3:8283211-8436019 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027535
 protein coding gene Chr3:6561165-6709068 (-)
PWK/PhJ MGP_PWKPhJ_G0025964
 protein coding gene Chr3:6610607-6754722 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025767
 protein coding gene Chr3:6703377-6850393 (-)
WSB/EiJ MGP_WSBEiJ_G0026300
 protein coding gene Chr3:6540229-6686381 (-)



Homology
more
  • Human Ortholog
    PAG1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAG1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  • Synonyms
    CBP, PAG
  • Links
    NCBI Gene ID: 55824
    neXtProt AC: NX_Q9NWQ8
    UniProt: Q9NWQ8

  • Chr Location
    8q21.13; chr8:80967810-81112068 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit no apparent defects in embryogenesis, thymic development, or T-cell functions. Mice homozygous for a different knock-out allele show normal T-cell development albeit with an increased thymocyte population.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027508 Ensembl Gene Model | MGI Sequence Detail 146201 C57BL/6J ±  kb
transcript ENSMUST00000161949 Ensembl | MGI Sequence Detail 8256 Not Applicable  
polypeptide ENSMUSP00000124529 Ensembl | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012231 phosphoprotein associated with glycosphingolipid-enriched microdomains 1
    (term hierarchy)
  • InterPro Domains
    IPR032748 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:71006 Brdicka T, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000 May 1;191(9):1591-604
  • Latest
    J:321685 Lucas RM, et al., SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Rep. 2021 Sep 7;36(10):109662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory