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Usp40 Gene Detail
Summary
  • Symbol
    Usp40
  • Name
    ubiquitin specific peptidase 40
  • Synonyms
    B230215L03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443184
    NCBI Gene: 227334
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87872841-87936273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443184
 protein coding gene Chr1:87872841-87936308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016272
 protein coding gene Chr1:89338659-89403659 (-)
A/J MGP_AJ_G0016253
 protein coding gene Chr1:85981185-86046422 (-)
AKR/J MGP_AKRJ_G0016214
 protein coding gene Chr1:88529082-88594598 (-)
BALB/cJ MGP_BALBcJ_G0016210
 protein coding gene Chr1:86109755-86173957 (-)
C3H/HeJ MGP_C3HHeJ_G0016038
 protein coding gene Chr1:88799327-88869529 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016667
 protein coding gene Chr1:92646064-92714313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014388
 protein coding gene Chr1:80425273-80474661 (-)
CAST/EiJ MGP_CASTEiJ_G0015623
 protein coding gene Chr1:87996554-88064634 (-)
CBA/J MGP_CBAJ_G0016014
 protein coding gene Chr1:95617648-95690579 (-)
DBA/2J MGP_DBA2J_G0016117
 protein coding gene Chr1:85271454-85334956 (-)
FVB/NJ MGP_FVBNJ_G0016116
 protein coding gene Chr1:84336103-84404588 (-)
LP/J MGP_LPJ_G0016188
 protein coding gene Chr1:90369871-90438713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016142
 protein coding gene Chr1:98869533-98936228 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016709
 protein coding gene Chr1:88638822-88706647 (-)
PWK/PhJ MGP_PWKPhJ_G0015410
 protein coding gene Chr1:84584423-84648940 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015190
 protein coding gene Chr1:87525961-87593711 (-)
WSB/EiJ MGP_WSBEiJ_G0015687
 protein coding gene Chr1:88302684-88368610 (-)



Homology
more
  • Human Ortholog
    USP40, ubiquitin specific peptidase 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP40, ubiquitin specific peptidase 40
  • Links
    NCBI Gene ID: 55230
    neXtProt AC: NX_Q9NVE5
    UniProt: Q9NVE5

  • Chr Location
    2q37.1; chr2:233475526-233566782 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    83
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005501 Ensembl Gene Model | MGI Sequence Detail 63433 C57BL/6J ±  kb
transcript ENSMUST00000187758 Ensembl | MGI Sequence Detail 3977 Not Applicable  
polypeptide ENSMUSP00000140107 Ensembl | MGI Sequence Detail 1235 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:346398 Miao J, et al., The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90beta. Exp Mol Med. 2024 Feb;56(2):395-407
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory