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Orai2 Gene Detail
Summary
  • Symbol
    Orai2
  • Name
    ORAI calcium release-activated calcium modulator 2
  • Synonyms
    A730041O15Rik, Tmem142b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443195
    NCBI Gene: 269717
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136176313-136199567 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    572 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443195
 protein coding gene Chr5:136176310-136201418 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030203
 protein coding gene Chr5:140778065-140802757 (-)
A/J MGP_AJ_G0030171
 protein coding gene Chr5:134713833-134733590 (-)
AKR/J MGP_AKRJ_G0030104
 protein coding gene Chr5:139066895-139086065 (-)
BALB/cJ MGP_BALBcJ_G0030181
 protein coding gene Chr5:136071281-136091027 (-)
C3H/HeJ MGP_C3HHeJ_G0029897
 protein coding gene Chr5:139688204-139708364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030634
 protein coding gene Chr5:146008030-146032857 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027854
 protein coding gene Chr5:128995148-129014347 (-)
CAST/EiJ MGP_CASTEiJ_G0029307
 protein coding gene Chr5:139091487-139113283 (-)
CBA/J MGP_CBAJ_G0029867
 protein coding gene Chr5:151715258-151741155 (-)
DBA/2J MGP_DBA2J_G0030018
 protein coding gene Chr5:134614113-134632992 (-)
FVB/NJ MGP_FVBNJ_G0029973
 protein coding gene Chr5:133768726-133788517 (-)
LP/J MGP_LPJ_G0030107
 protein coding gene Chr5:141199807-141225723 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030005
 protein coding gene Chr5:154686230-154711118 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030674
 protein coding gene Chr5:138885042-138905727 (-)
PWK/PhJ MGP_PWKPhJ_G0029020
 protein coding gene Chr5:133674426-133696608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028856
 protein coding gene Chr5:136434254-136455898 (-)
WSB/EiJ MGP_WSBEiJ_G0029380
 protein coding gene Chr5:139607975-139633741 (-)



Homology
more
  • Human Ortholog
    ORAI2, ORAI calcium release-activated calcium modulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORAI2, ORAI calcium release-activated calcium modulator 2
  • Synonyms
    C7orf19, CBCIP2, MEM142B, TMEM142B
  • Links
    NCBI Gene ID: 80228
    neXtProt AC: NX_Q96SN7
    UniProt: Q96SN7

  • Chr Location
    7q22.1; chr7:102433106-102456825 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO mice show increased SOCE (store-operated Ca2+ entry) through CRAC (Ca2+ release-activated Ca2+) channels in T cells and higher CRAC currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    29
  • cDNA Data
    36
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039747 Ensembl Gene Model | MGI Sequence Detail 23255 C57BL/6J ±  kb
transcript ENSMUST00000196454 Ensembl | MGI Sequence Detail 3990 Not Applicable  
polypeptide ENSMUSP00000142597 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 5
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:327947 Bieber M, et al., Blockade of Platelet Glycoprotein Ibalpha Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion. Int J Mol Sci. 2022 Aug 22;23(16)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory