Rbm15 MGI Mouse Gene Detail - MGI:2443205 - RNA binding motif protein 15

Symbol

Rbm15
Name

RNA binding motif protein 15
Synonyms

C230088J01Rik

Feature Type

protein coding gene
IDs

MGI:2443205
NCBI Gene: 229700
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:107232737-107240989 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.83 cM
Mapping Data

1 experiment

SNPs within 2kb

111 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443205	protein coding gene	Chr3:107212827-107244102 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027747	protein coding gene	Chr3:108805643-108814873 (-)
A/J	MGP_AJ_G0027707	protein coding gene	Chr3:105361087-105369352 (-)
AKR/J	MGP_AKRJ_G0027672	protein coding gene	Chr3:107936926-107945160 (-)
BALB/cJ	MGP_BALBcJ_G0027719	protein coding gene	Chr3:105059833-105068359 (-)
C3H/HeJ	MGP_C3HHeJ_G0027449	protein coding gene	Chr3:108277310-108285586 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028163	protein coding gene	Chr3:112885810-112894097 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025501	protein coding gene	Chr3:101524322-101532555 (-)
CAST/EiJ	MGP_CASTEiJ_G0026905	protein coding gene	Chr3:107655590-107664842 (-)
CBA/J	MGP_CBAJ_G0027424	protein coding gene	Chr3:116702683-116710909 (-)
DBA/2J	MGP_DBA2J_G0027566	protein coding gene	Chr3:104563736-104571988 (-)
FVB/NJ	MGP_FVBNJ_G0027534	protein coding gene	Chr3:102443760-102452635 (-)
LP/J	MGP_LPJ_G0027673	protein coding gene	Chr3:110224828-110233068 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027564	protein coding gene	Chr3:122830094-122840799 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028218	protein coding gene	Chr3:107529744-107537969 (-)
PWK/PhJ	MGP_PWKPhJ_G0026631	protein coding gene	Chr3:104290933-104299206 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026451	protein coding gene	Chr3:105661409-105669630 (-)
WSB/EiJ	MGP_WSBEiJ_G0026985	protein coding gene	Chr3:108051757-108062887 (-)

Human Ortholog

RBM15, RNA binding motif protein 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM15, RNA binding motif protein 15
Synonyms

OTT, OTT1, SPEN
Links

HGNC:14959

NCBI Gene ID: 64783

neXtProt AC: NX_Q96T37

UniProt: Q96T37
Chr Location

1p13.3; chr1:110338506-110346681 (+) GRCh38

MGI Vertebrate Homology

Rbm15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM15
Gene Tree

Rbm15

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 4 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Rbm15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality around E9.5. Mice homozygous for a floxed allele activate in hematopoietic cells exhibit increased megakaryocyte cell number, long-term hematopoietic stem cells, and red pulp as well as decreased B cells and leukocytes.

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

31
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm15

ZFIN rbm15

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All Sequences

46
RefSeq

6
UniProt

1
CCDS

CCDS38590.1

Ensembl

ENSMUSG00000048109 (Evidence)
NCBI Gene

229700

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048109	Ensembl Gene Model \| MGI Sequence Detail	8253	C57BL/6J	± kb
transcript	ENSMUST00000061772	Ensembl \| MGI Sequence Detail	4343	Not Applicable
polypeptide	ENSMUSP00000054424	Ensembl \| MGI Sequence Detail	962	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029709 RNA-binding protein 15

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034470 RBM15, RNA recognition motif 1

IPR034472 RBM15, RNA recognition motif 2

IPR034473 RBM15, RNA recognition motif 3

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR012921 Spen paralogue and orthologue SPOC, C-terminal

IPR010912 Spen paralogue/orthologue C-terminal, metazoa

IPR016194 SPOC-like, C-terminal domain superfamily
GlyGen

Q0VBL3 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 15

Genomic 1

cDNA 12

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 15
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Rbm15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35060	Chr3:107241269-107241289 (-)	-290 bp
Tssr35059	Chr3:107240340-107240385 (-)	626 bp
Tssr35058	Chr3:107240328-107240339 (-)	655 bp
Tssr35057	Chr3:107237221-107237261 (-)	3,748 bp
Tssr35056	Chr3:107233890-107233894 (-)	7,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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