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Gatad2b Gene Detail
Summary
  • Symbol
    Gatad2b
  • Name
    GATA zinc finger domain containing 2B
  • Synonyms
    C430014D17Rik, p66beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443225
    NCBI Gene: 229542
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90200488-90270712 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443225
 protein coding gene Chr3:90200485-90270714 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027461
 protein coding gene Chr3:90589634-90669538 (+)
A/J MGP_AJ_G0027425
 protein coding gene Chr3:87577675-87651489 (+)
AKR/J MGP_AKRJ_G0027390
 protein coding gene Chr3:89724550-89806239 (+)
BALB/cJ MGP_BALBcJ_G0027434
 protein coding gene Chr3:87537076-87609143 (+)
C3H/HeJ MGP_C3HHeJ_G0027176
 protein coding gene Chr3:89893416-89968364 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027880
 protein coding gene Chr3:93996610-94076096 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025233
 protein coding gene Chr3:83074498-83146831 (+)
CAST/EiJ MGP_CASTEiJ_G0026622
 protein coding gene Chr3:90275558-90351597 (+)
CBA/J MGP_CBAJ_G0027151
 protein coding gene Chr3:97231875-97302790 (+)
DBA/2J MGP_DBA2J_G0027288
 protein coding gene Chr3:86947787-87020428 (+)
FVB/NJ MGP_FVBNJ_G0027256
 protein coding gene Chr3:85283264-85354413 (+)
LP/J MGP_LPJ_G0027397
 protein coding gene Chr3:91659413-91733741 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027277
 protein coding gene Chr3:103444881-103519292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027939
 protein coding gene Chr3:89478053-89551784 (+)
PWK/PhJ MGP_PWKPhJ_G0026356
 protein coding gene Chr3:86836140-86909359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026176
 protein coding gene Chr3:88659546-88731333 (+)
WSB/EiJ MGP_WSBEiJ_G0026704
 protein coding gene Chr3:89875483-89949511 (+)



Homology
more
  • Human Ortholog
    GATAD2B, GATA zinc finger domain containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATAD2B, GATA zinc finger domain containing 2B
  • Synonyms
    GANDS, MRD18, P66beta, p68
  • Links
    NCBI Gene ID: 57459
    neXtProt AC: NX_Q8WXI9
    UniProt: Q8WXI9

  • Chr Location
    1q21.3; chr1:153789030-153923360 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gatad2b mouse models; 1 with human GATAD2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die perinatally. Heterozygotes survive to adulthood but exhibit a broad snout, an elevated nasion, abnormal cortical neuron development, and behavioral and learning abnormalities resembling the clinical features of GAND patients.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    23
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229542 NCBI Gene Model | MGI Sequence Detail 70225 C57BL/6J ±  kb
    transcript NM_001379655 RefSeq | MGI Sequence Detail 7484 C57BL/6  
    polypeptide Q8VHR5 UniProt | EBI | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007863 transcriptional repressor p66-beta
      (term hierarchy)
    • InterPro Domains
      IPR040386 Transcriptional repressor p66
      IPR032346 Transcriptional repressor p66, coiled-coil MBD2-interaction domain
      IPR000679 Zinc finger, GATA-type
      IPR013088 Zinc finger, NHR/GATA-type
    • GlyGen
      Q8VHR5 12 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3034967
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory