Rnf222 Gene Detail

Summary

• Symbol
  Rnf222
• Name
  ring finger protein 222
• Synonyms
  9930039A11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2443227
  NCBI Gene: 320040
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr11:68779379-68786603 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 42.16 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  249 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443227	protein coding gene	Chr11:68772947-68786605 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018506	protein coding gene	Chr11:69269727-69276951 (+)
A/J	MGP_AJ_G0018475	protein coding gene	Chr11:66675417-66682644 (+)
AKR/J	MGP_AKRJ_G0018444	protein coding gene	Chr11:68663544-68670828 (+)
BALB/cJ	MGP_BALBcJ_G0018446	protein coding gene	Chr11:66969614-66976848 (+)
C3H/HeJ	MGP_C3HHeJ_G0018259	protein coding gene	Chr11:68687119-68694348 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018898	protein coding gene	Chr11:71377768-71385021 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016542	protein coding gene	Chr11:63612990-63620378 (+)
CAST/EiJ	MGP_CASTEiJ_G0017815	protein coding gene	Chr11:68919962-68927173 (+)
CBA/J	MGP_CBAJ_G0018233	protein coding gene	Chr11:74545450-74552686 (+)
DBA/2J	MGP_DBA2J_G0018342	protein coding gene	Chr11:66272383-66279607 (+)
FVB/NJ	MGP_FVBNJ_G0018332	protein coding gene	Chr11:65893828-65901071 (+)
LP/J	MGP_LPJ_G0018413	protein coding gene	Chr11:69850316-69858350 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018355	protein coding gene	Chr11:75229414-75236834 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018939	protein coding gene	Chr11:68909576-68916823 (+)
PWK/PhJ	MGP_PWKPhJ_G0017590	protein coding gene	Chr11:66898530-66905773 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017378	protein coding gene	Chr11:68742365-68749561 (+)
WSB/EiJ	MGP_WSBEiJ_G0017868	protein coding gene	Chr11:68547733-68554951 (+)

Homology

• Human Ortholog
  RNF222, ring finger protein 222

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RNF222, ring finger protein 222
  
• Links
  HGNC:34517

  NCBI Gene ID: 643904

  neXtProt AC: NX_A6NCQ9

  UniProt: A6NCQ9

  
  
• Chr Location
  17p13.1; chr17:8390702-8397827 (-)  GRCh38

---

• MGI Vertebrate Homology
  Rnf222 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: RNF222
• Gene Tree
  Rnf222
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Targeted
  4
• Genomic Mutations
  1 involving Rnf222
• Find Mice (IMSR)
  15 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  17
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rnf222

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  8
• UniProt
  1
• CCDS
  CCDS24871.1

• Ensembl
  ENSMUSG00000046490 (Evidence)
• NCBI Gene
  320040

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046490	Ensembl Gene Model | MGI Sequence Detail	7225	C57BL/6J
transcript	ENSMUST00000065213	Ensembl | MGI Sequence Detail	3463	Not Applicable
polypeptide	ENSMUSP00000067364	Ensembl | MGI Sequence Detail	211	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000030394 RING finger protein 222
  (term hierarchy)
• InterPro Domains
  IPR042973 RING finger protein 222
  IPR013083 Zinc finger, RING/FYVE/PHD-type
  IPR001841 Zinc finger, RING-type
  IPR017907 Zinc finger, RING-type, conserved site
  IPR027370 Zinc finger, RING-type, eukaryotic

Molecular
Reagents

• All nucleic 17

  cDNA 17

  
  

  Microarray probesets 3

References

• Summaries
  All 27

  Developmental Gene Expression 1

  Gene Ontology 2

  Phenotypes 8
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:356096 de Barros Mucci D, et al., Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 May;44(5):1087-1096

TSS for Rnf222:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102344	Chr11:68779343-68779349 (+)	-33 bp
Tssr102345	Chr11:68779371-68779388 (+)	1 bp
Tssr102346	Chr11:68779404-68779414 (+)	30 bp
Tssr102347	Chr11:68779420-68779431 (+)	47 bp