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Agfg2 Gene Detail
Summary
  • Symbol
    Agfg2
  • Name
    ArfGAP with FG repeats 2
  • Synonyms
    A630095P14Rik, Hrbl, MGC:61203, MGC:7148
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443267
    NCBI Gene: 231801
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137648725-137682988 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1092 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443267
 protein coding gene Chr5:137648725-137683068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030240
 protein coding gene Chr5:142428662-142464979 (-)
A/J MGP_AJ_G0030208
 protein coding gene Chr5:136216011-136254127 (-)
AKR/J MGP_AKRJ_G0030141
 protein coding gene Chr5:140644731-140679621 (-)
BALB/cJ MGP_BALBcJ_G0030218
 protein coding gene Chr5:137592638-137626543 (-)
C3H/HeJ MGP_C3HHeJ_G0029934
 protein coding gene Chr5:141297522-141342580 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030670
 protein coding gene Chr5:147688554-147730042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027888
 protein coding gene Chr5:130459504-130493567 (-)
CAST/EiJ MGP_CASTEiJ_G0029344
 protein coding gene Chr5:140698777-140737646 (-)
CBA/J MGP_CBAJ_G0029904
 protein coding gene Chr5:153566201-153612281 (-)
DBA/2J MGP_DBA2J_G0030055
 protein coding gene Chr5:136117852-136152399 (-)
FVB/NJ MGP_FVBNJ_G0030010
 protein coding gene Chr5:135325394-135360879 (-)
LP/J MGP_LPJ_G0030144
 protein coding gene Chr5:142901972-142943544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030042
 protein coding gene Chr5:156378996-156415371 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030711
 protein coding gene Chr5:140495756-140534858 (-)
PWK/PhJ MGP_PWKPhJ_G0029057
 protein coding gene Chr5:135208688-135247949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028893
 protein coding gene Chr5:138066871-138102121 (-)
WSB/EiJ MGP_WSBEiJ_G0029417
 protein coding gene Chr5:141227683-141266772 (-)



Homology
more
  • Human Ortholog
    AGFG2, ArfGAP with FG repeats 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGFG2, ArfGAP with FG repeats 2
  • Synonyms
    HRBL, RABR
  • Links
    NCBI Gene ID: 3268
    neXtProt AC: NX_O95081
    UniProt: O95081

  • Chr Location
    7q22.1; chr7:100539203-100568220 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    6
  • cDNA Data
    43
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029722 Ensembl Gene Model | MGI Sequence Detail 34264 C57BL/6J ±  kb
transcript ENSMUST00000100544 Ensembl | MGI Sequence Detail 2858 Not Applicable  
polypeptide ENSMUSP00000098112 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029263 Arf-GAP domain and FG repeat-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR052248 Arf-GAP domain and FG repeat-containing protein
    IPR038508 ArfGAP domain superfamily
    IPR037278 ARFGAP/RecO-like zinc finger
    IPR001164 Arf GTPase activating protein
  • GlyGen
    Q80WC7 6 sites, 1 O-linked glycan (6 sites)
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:113837 Coda L, et al., Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. J Biol Chem. 1998 Jan 30;273(5):3003-12
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory