Unc45b MGI Mouse Gene Detail - MGI:2443377

Symbol

Unc45b
Name

unc-45 myosin chaperone B
Synonyms

Cmya4, D230041A13Rik, UNC45

Feature Type

protein coding gene
IDs

MGI:2443377
NCBI Gene: 217012
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:82802112-82834284 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM
Mapping Data

2 experiments

SNPs within 2kb

999 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443377	protein coding gene	Chr11:82801376-82834284 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018835	protein coding gene	Chr11:84199679-84232527 (+)
A/J	MGP_AJ_G0018802	protein coding gene	Chr11:80960168-80993860 (+)
AKR/J	MGP_AKRJ_G0018772	protein coding gene	Chr11:83391211-83432600 (+)
BALB/cJ	MGP_BALBcJ_G0018775	protein coding gene	Chr11:81363736-81399714 (+)
C3H/HeJ	MGP_C3HHeJ_G0018589	protein coding gene	Chr11:83421091-83456036 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019227	protein coding gene	Chr11:86717693-86754256 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016861	protein coding gene	Chr11:77923359-77953244 (+)
CAST/EiJ	MGP_CASTEiJ_G0018144	protein coding gene	Chr11:84011436-84042037 (+)
CBA/J	MGP_CBAJ_G0018560	protein coding gene	Chr11:90471461-90507307 (+)
DBA/2J	MGP_DBA2J_G0018668	protein coding gene	Chr11:80534710-80568850 (+)
FVB/NJ	MGP_FVBNJ_G0018657	protein coding gene	Chr11:80060092-80092983 (+)
LP/J	MGP_LPJ_G0018738	protein coding gene	Chr11:84709366-84745577 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018684	protein coding gene	Chr11:90667868-90703666 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019267	protein coding gene	Chr11:83649920-83681032 (+)
PWK/PhJ	MGP_PWKPhJ_G0017914	protein coding gene	Chr11:81356972-81393003 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017705	protein coding gene	Chr11:83272945-83313815 (+)
WSB/EiJ	MGP_WSBEiJ_G0018196	protein coding gene	Chr11:83536515-83570085 (+)

Human Ortholog

UNC45B, unc-45 myosin chaperone B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC45B, unc-45 myosin chaperone B
Synonyms

CMYA4, CTRCT43, MFM11, SMUNC45, UNC45, UNC-45B
Links

HGNC:14304

NCBI Gene ID: 146862

neXtProt AC: NX_Q8IWX7

UniProt: Q8IWX7
Chr Location

17q12

MGI Vertebrate Homology

Unc45b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UNC45B
Gene Tree

Unc45b

Diseases

2 with human UNC45B associations

				Human Disease	Mouse Models
				cataract 43 IDs cataract 43 DOID:0110259 ICD10CM:Q12.0 OMIM:616279
				myofibrillar myopathy 11 IDs myofibrillar myopathy 11 DOID:0081338 OMIM:619178

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Transgenic

1
Genomic Mutations

2 involving Unc45b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

12
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase unc45b

ZFIN unc45b

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All Sequences

43
RefSeq

4
UniProt

1
CCDS

CCDS36251.1

Ensembl

ENSMUSG00000018845 (Evidence)
NCBI Gene

217012

			Length	Strain/Species	Flank
genomic	217012	NCBI Gene Model \| MGI Sequence Detail	32173	C57BL/6J	± kb
transcript	NM_178680	RefSeq \| MGI Sequence Detail	3571	C57BL/6
polypeptide	Q8CGY6	UniProt \| EBI \| MGI Sequence Detail	931	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017091 protein unc-45 homolog B

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR024660 UNC-45/Cro1/She4, central domain
GlyGen

Q8CGY6 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 2

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MGI:2671016

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Unc45b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103587	Chr11:82802105-82802120 (+)	1 bp
Tssr103588	Chr11:82802135-82802157 (+)	34 bp
Tssr103589	Chr11:82824310-82824314 (+)	22,200 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24