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Lrch1 Gene Detail
Summary
  • Symbol
    Lrch1
  • Name
    leucine-rich repeats and calponin homology (CH) domain containing 1
  • Synonyms
    4832412D13Rik, Chdc1, mKIAA1016
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443390
    NCBI Gene: 380916
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:74992115-75185316 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443390
 protein coding gene Chr14:74992113-75185447 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021564
 protein coding gene Chr14:69548563-69743110 (-)
A/J MGP_AJ_G0021522
 protein coding gene Chr14:68000478-68193134 (-)
AKR/J MGP_AKRJ_G0021499
 protein coding gene Chr14:70025382-70215661 (-)
BALB/cJ MGP_BALBcJ_G0021529
 protein coding gene Chr14:67793362-67993796 (-)
C3H/HeJ MGP_C3HHeJ_G0021306
 protein coding gene Chr14:69762349-69953951 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021969
 protein coding gene Chr14:72589480-72806515 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019507
 protein coding gene Chr14:65651263-65836619 (-)
CAST/EiJ MGP_CASTEiJ_G0020823
 protein coding gene Chr14:66411701-66605247 (-)
CBA/J MGP_CBAJ_G0021274
 protein coding gene Chr14:74925298-75130474 (-)
DBA/2J MGP_DBA2J_G0021397
 protein coding gene Chr14:67420234-67608225 (-)
FVB/NJ MGP_FVBNJ_G0021375
 protein coding gene Chr14:66747668-66936250 (-)
LP/J MGP_LPJ_G0021467
 protein coding gene Chr14:70711590-70902786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021402
 protein coding gene Chr14:73715520-73920644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021992
 protein coding gene Chr14:69306306-69496510 (-)
PWK/PhJ MGP_PWKPhJ_G0020566
 protein coding gene Chr14:64147829-64334601 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020402
 protein coding gene Chr14:65258143-65449600 (-)
WSB/EiJ MGP_WSBEiJ_G0020876
 protein coding gene Chr14:69640934-69844572 (-)



Homology
more
  • Human Ortholog
    LRCH1, leucine rich repeats and calponin homology domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRCH1, leucine rich repeats and calponin homology domain containing 1
  • Synonyms
    CHDC1, NP81
  • Links
    NCBI Gene ID: 23143
    neXtProt AC: NX_Q9Y2L9
    UniProt: Q9Y2L9

  • Chr Location
    13q14.13-q14.2; chr13:46553168-46753041 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lrch1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to increased susceptibility to experimental autoimmune encephalomyelitis as a result of increased migration of T cells into the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    24
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068015 Ensembl Gene Model | MGI Sequence Detail 193202 C57BL/6J ±  kb
transcript ENSMUST00000088970 Ensembl | MGI Sequence Detail 4694 Not Applicable  
polypeptide ENSMUSP00000086363 Ensembl | MGI Sequence Detail 709 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 9
Other
Accession IDs
less
MGI:2145669, MGI:2145806
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory