Cd300a MGI Mouse Gene Detail - MGI:2443411

Symbol

Cd300a
Name

CD300A molecule
Synonyms

B230315M08Rik, Clm8, LMIR1, MAIR-I, MMAC8, Pigr4

Feature Type

protein coding gene
IDs

MGI:2443411
NCBI Gene: 217303
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:114780006-114792772 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.54 cM
Mapping Data

2 experiments

SNPs within 2kb

504 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443411	protein coding gene	Chr11:114780006-114795480 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019363	protein coding gene	Chr11:118846760-118861916 (+)
A/J	MGP_AJ_G0019332	protein coding gene	Chr11:113678574-113693791 (+)
AKR/J	MGP_AKRJ_G0019300	protein coding gene	Chr11:117044558-117059179 (+)
BALB/cJ	MGP_BALBcJ_G0019305	protein coding gene	Chr11:114088629-114103533 (+)
C3H/HeJ	MGP_C3HHeJ_G0019114	protein coding gene	Chr11:117394395-117409141 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019756	protein coding gene	Chr11:122413357-122429336 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017379	protein coding gene	Chr11:110737831-110776016 (+)
CAST/EiJ	MGP_CASTEiJ_G0018668	protein coding gene	Chr11:118727748-118743217 (+)
CBA/J	MGP_CBAJ_G0019084	protein coding gene	Chr11:127324797-127339661 (+)
DBA/2J	MGP_DBA2J_G0019196	protein coding gene	Chr11:113115022-113129632 (+)
FVB/NJ	MGP_FVBNJ_G0019187	protein coding gene	Chr11:112597736-112612561 (+)
LP/J	MGP_LPJ_G0019266	protein coding gene	Chr11:119254993-119269727 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019218	protein coding gene	Chr11:126457671-126473827 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019793	protein coding gene	Chr11:117715985-117730596 (+)
PWK/PhJ	MGP_PWKPhJ_G0018433	protein coding gene	Chr11:114351001-114367709 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018225	protein coding gene	Chr11:117521284-117540149 (+)
WSB/EiJ	MGP_WSBEiJ_G0018720	protein coding gene	Chr11:117676711-117690791 (+)

Human Ortholog

CD300A, CD300a molecule

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD300A, CD300a molecule
Synonyms

CLM-8, CMRF-35H, CMRF35-H, CMRF35H, CMRF-35-H9, CMRF35-H9, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60
Links

HGNC:19319

NCBI Gene ID: 11314

neXtProt AC: NX_Q9UGN4

UniProt: Q9UGN4
Chr Location

17q25.1; chr17:74466373-74484798 (+) GRCh38

MGI Vertebrate Homology

Cd300a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CD300A
Gene Tree

Cd300a

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased susceptibility to cecal ligation and puncture with increased production of chemoattractants by mast cells.

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All GO Annotations

33
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

8
UniProt

1
CCDS

CCDS25613.1, CCDS83923.1

Ensembl

ENSMUSG00000034652 (Evidence)
NCBI Gene

217303

			Length	Strain/Species	Flank
genomic	217303	NCBI Gene Model \| MGI Sequence Detail	12767	C57BL/6J	± kb
transcript	NM_001359812	RefSeq \| MGI Sequence Detail	2030	ZRU/MplStud
polypeptide	Q6SJQ0	UniProt \| EBI \| MGI Sequence Detail	318	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001414 CMRF35-like molecule 8

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q6SJQ0 1 site

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All nucleic 11

cDNA 10

Other 1

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 24
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cd300a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105810	Chr11:114781010-114781029 (+)	1,014 bp
Tssr105811	Chr11:114781041-114781052 (+)	1,041 bp
Tssr105812	Chr11:114781098-114781196 (+)	1,141 bp
Tssr105813	Chr11:114781203-114781212 (+)	1,202 bp
Tssr105814	Chr11:114781838-114781871 (+)	1,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24