Rps6kl1 MGI Mouse Gene Detail - MGI:2443413 - ribosomal protein S6 kinase-like 1

Symbol

Rps6kl1
Name

ribosomal protein S6 kinase-like 1
Synonyms

A830084F09Rik

Feature Type

protein coding gene
IDs

MGI:2443413
NCBI Gene: 238323
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:85182023-85198038 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.57 cM
Mapping Data

2 experiments

SNPs within 2kb

489 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443413	protein coding gene	Chr12:85182023-85198052 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019953	protein coding gene	Chr12:85894557-85910241 (-)
A/J	MGP_AJ_G0019910	protein coding gene	Chr12:82641875-82658592 (-)
AKR/J	MGP_AKRJ_G0019886	protein coding gene	Chr12:84866806-84886134 (-)
BALB/cJ	MGP_BALBcJ_G0019890	protein coding gene	Chr12:82976279-82995588 (-)
C3H/HeJ	MGP_C3HHeJ_G0019696	protein coding gene	Chr12:85344611-85362249 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020341	protein coding gene	Chr12:88368287-88383987 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017959	protein coding gene	Chr12:79524319-79539821 (-)
CAST/EiJ	MGP_CASTEiJ_G0019245	protein coding gene	Chr12:80318219-80335586 (-)
CBA/J	MGP_CBAJ_G0019667	protein coding gene	Chr12:91767245-91782935 (-)
DBA/2J	MGP_DBA2J_G0019782	protein coding gene	Chr12:82154735-82170609 (-)
FVB/NJ	MGP_FVBNJ_G0019768	protein coding gene	Chr12:81115950-81131644 (-)
LP/J	MGP_LPJ_G0019854	protein coding gene	Chr12:85770813-85786503 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019807	protein coding gene	Chr12:94637361-94653034 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020375	protein coding gene	Chr12:84476525-84493139 (-)
PWK/PhJ	MGP_PWKPhJ_G0019009	protein coding gene	Chr12:76646372-76662342 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018804	protein coding gene	Chr12:78958597-78975132 (-)
WSB/EiJ	MGP_WSBEiJ_G0019297	protein coding gene	Chr12:85194953-85212829 (-)

Human Ortholog

RPS6KL1, ribosomal protein S6 kinase like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KL1, ribosomal protein S6 kinase like 1
Synonyms

RSKL2
Links

HGNC:20222

NCBI Gene ID: 83694

neXtProt AC: NX_Q9Y6S9

UniProt: Q9Y6S9
Chr Location

14q24.3; chr14:74903951-74923302 (-) GRCh38

MGI Vertebrate Homology

Rps6kl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS6KL1
Gene Tree

Rps6kl1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Rps6kl1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

993
Tissues

48
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps6kl1

ZFIN rps6kl1

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All Sequences

52
RefSeq

16
UniProt

2
CCDS

CCDS36496.1

Ensembl

ENSMUSG00000019235 (Evidence)
NCBI Gene

238323

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019235	Ensembl Gene Model \| MGI Sequence Detail	16016	C57BL/6J	± kb
transcript	ENSMUST00000221972	Ensembl \| MGI Sequence Detail	2881	Not Applicable
polypeptide	ENSMUSP00000152336	Ensembl \| MGI Sequence Detail	544	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014289 ribosomal protein S6 kinase-like 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR051866 Intracellular Signaling and Trafficking Protein

IPR007330 MIT domain

IPR036181 MIT domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR035053 RPK118-like, kinase domain

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2144994

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rps6kl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117057	Chr12:85198038-85198049 (-)	-6 bp
Tssr117056	Chr12:85197987-85198034 (-)	27 bp
Tssr117055	Chr12:85187223-85187256 (-)	10,798 bp
Tssr117054	Chr12:85185526-85185538 (-)	12,506 bp
Tssr117053	Chr12:85185507-85185517 (-)	12,526 bp
Tssr117052	Chr12:85185476-85185506 (-)	12,547 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24