Tmem74 MGI Mouse Gene Detail - MGI:2443417

Symbol

Tmem74
Name

transmembrane protein 74
Synonyms

B230382K22Rik

Feature Type

protein coding gene
IDs

MGI:2443417
NCBI Gene: 239408
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:43728042-43733432 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 16.82 cM
Mapping Data

2 experiments

SNPs within 2kb

243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443417	protein coding gene	Chr15:43726741-43733462 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021827	protein coding gene	Chr15:42463320-42466632 (-)
A/J	MGP_AJ_G0021787	protein coding gene	Chr15:40847711-40851081 (-)
AKR/J	MGP_AKRJ_G0021768	protein coding gene	Chr15:42041790-42045484 (-)
BALB/cJ	MGP_BALBcJ_G0021794	protein coding gene	Chr15:40929901-40933235 (-)
C3H/HeJ	MGP_C3HHeJ_G0021568	protein coding gene	Chr15:41957993-41961325 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022233	protein coding gene	Chr15:44107261-44110753 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019770	protein coding gene	Chr15:38402721-38406023 (-)
CAST/EiJ	MGP_CASTEiJ_G0021085	protein coding gene	Chr15:42488906-42492250 (-)
CBA/J	MGP_CBAJ_G0021537	protein coding gene	Chr15:45639064-45642404 (-)
DBA/2J	MGP_DBA2J_G0021661	protein coding gene	Chr15:40659882-40663212 (-)
FVB/NJ	MGP_FVBNJ_G0021639	protein coding gene	Chr15:39965310-39968662 (-)
LP/J	MGP_LPJ_G0021731	protein coding gene	Chr15:42239717-42243045 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021663	protein coding gene	Chr15:48988034-48991348 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022256	protein coding gene	Chr15:42243932-42247262 (-)
PWK/PhJ	MGP_PWKPhJ_G0020830	protein coding gene	Chr15:40695459-40698841 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020667	protein coding gene	Chr15:41895520-41898840 (-)
WSB/EiJ	MGP_WSBEiJ_G0021140	protein coding gene	Chr15:42138909-42142231 (-)

Human Ortholog

TMEM74, transmembrane protein 74

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM74, transmembrane protein 74
Synonyms

NET36
Links

HGNC:26409

NCBI Gene ID: 157753

neXtProt AC: NX_Q96NL1

UniProt: Q96NL1
Chr Location

8q23.1; chr8:108606850-108787594 (-) GRCh38

MGI Vertebrate Homology

Tmem74 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TMEM74
Gene Tree

Tmem74

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

5
Targeted

2
Genomic Mutations

2 involving Tmem74
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects basolateral amygdaloid nucleus (BLA) pyramidal neuron electrophysiology, leading to increased anxiety-like behavior.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

5
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem74

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS27454.1

Ensembl

ENSMUSG00000054409 (Evidence)
NCBI Gene

239408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054409	Ensembl Gene Model \| MGI Sequence Detail	5391	C57BL/6J	± kb
transcript	ENSMUST00000067469	Ensembl \| MGI Sequence Detail	3528	Not Applicable
polypeptide	ENSMUSP00000070748	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031346 transmembrane protein 74

(term hierarchy)
InterPro Domains

IPR029695 Transmembrane protein 74-like

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All nucleic 5

cDNA 5

Microarray probesets 2

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MGI:3034807

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem74:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134193	Chr15:43733389-43733454 (-)	10 bp
Tssr134192	Chr15:43733367-43733372 (-)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24