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Trmt61a Gene Detail
Summary
  • Symbol
    Trmt61a
  • Name
    tRNA methyltransferase 61A
  • Synonyms
    6720458F09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443487
    NCBI Gene: 328162
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111644539-111650336 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443487
 protein coding gene Chr12:111644539-111650336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020138
 protein coding gene Chr12:114079691-114085485 (+)
A/J MGP_AJ_G0020094
 protein coding gene Chr12:109700490-109707066 (+)
AKR/J MGP_AKRJ_G0020069
 protein coding gene Chr12:112836892-112845166 (+)
BALB/cJ MGP_BALBcJ_G0020079
 protein coding gene Chr12:110124137-110129941 (+)
C3H/HeJ MGP_C3HHeJ_G0019881
 protein coding gene Chr12:113339743-113347358 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020524
 protein coding gene Chr12:117622554-117628304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018137
 protein coding gene Chr12:106140071-106146363 (+)
CAST/EiJ MGP_CASTEiJ_G0019422
 protein coding gene Chr12:108181269-108189626 (+)
CBA/J MGP_CBAJ_G0019848
 protein coding gene Chr12:122096394-122102906 (+)
DBA/2J MGP_DBA2J_G0019965
 protein coding gene Chr12:109176319-109182806 (+)
FVB/NJ MGP_FVBNJ_G0019950
 protein coding gene Chr12:107977788-107984244 (+)
LP/J MGP_LPJ_G0020040
 protein coding gene Chr12:113906315-113912110 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019988
 protein coding gene Chr12:125230659-125238170 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020553
 protein coding gene Chr12:112360647-112367416 (+)
PWK/PhJ MGP_PWKPhJ_G0019183
 protein coding gene Chr12:103821476-103827432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018986
 protein coding gene Chr12:106528867-106535183 (+)
WSB/EiJ MGP_WSBEiJ_G0019481
 protein coding gene Chr12:113269790-113277506 (+)



Homology
more
  • Human Ortholog
    TRMT61A, tRNA methyltransferase 61A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRMT61A, tRNA methyltransferase 61A
  • Synonyms
    C14orf172, GCD14, Gcd14p, hTRM61, TRM61
  • Links
    NCBI Gene ID: 115708
    neXtProt AC: NX_Q96FX7
    UniProt: Q96FX7

  • Chr Location
    14q32.33
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased CD4+ T cells and stimulated T cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 328162 NCBI Gene Model | MGI Sequence Detail 5798 C57BL/6J ±  kb
    transcript NM_177374 RefSeq | MGI Sequence Detail 2441 C57BL/6  
    polypeptide Q80XC2 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016684 tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
      (term hierarchy)
    • EC
      2.1.1.-, 2.1.1.220
    • InterPro Domains
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14
      IPR049470 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144866
    References
    more
    • Summaries
      All 37
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:336736 Liu Y, et al., tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis. Nat Immunol. 2022 Oct;23(10):1433-1444
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory