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Slc9a6 Gene Detail
Summary
  • Symbol
    Slc9a6
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 6
  • Synonyms
    6430520C02Rik, mKIAA0267, NHE6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443511
    NCBI Gene: 236794
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:55655117-55709590 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 30.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    999 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443511
 protein coding gene ChrX:55654921-55709590 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035739
 protein coding gene ChrX:51905819-51962121 (+)
A/J MGP_AJ_G0035722
 protein coding gene ChrX:52095344-52150142 (+)
AKR/J MGP_AKRJ_G0035642
 protein coding gene ChrX:53486073-53544458 (+)
BALB/cJ MGP_BALBcJ_G0035709
 protein coding gene ChrX:51570449-51624892 (+)
C3H/HeJ MGP_C3HHeJ_G0035411
 protein coding gene ChrX:52444000-52501629 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036238
 protein coding gene ChrX:53291785-53349114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033089
 protein coding gene ChrX:51541652-51596420 (+)
CAST/EiJ MGP_CASTEiJ_G0034704
 protein coding gene ChrX:38332872-38387516 (+)
CBA/J MGP_CBAJ_G0035386
 protein coding gene ChrX:54842884-54902774 (+)
DBA/2J MGP_DBA2J_G0035540
 protein coding gene ChrX:51698802-51753108 (+)
FVB/NJ MGP_FVBNJ_G0035490
 protein coding gene ChrX:51296975-51351899 (+)
LP/J MGP_LPJ_G0035628
 protein coding gene ChrX:52496617-52551677 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035526
 protein coding gene ChrX:56383363-56439417 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036254
 protein coding gene ChrX:51938742-51994874 (+)
PWK/PhJ MGP_PWKPhJ_G0034400
 protein coding gene ChrX:36601691-36659314 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034244
 protein coding gene ChrX:39057733-39112937 (+)
WSB/EiJ MGP_WSBEiJ_G0034847
 protein coding gene ChrX:51472466-51527566 (+)



Homology
more
  • Human Ortholog
    SLC9A6, solute carrier family 9 member A6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A6, solute carrier family 9 member A6
  • Synonyms
    MRSA, MRXSCH, NHE6
  • Links
    NCBI Gene ID: 10479
    neXtProt AC: NX_Q92581
    UniProt: Q92581

  • Chr Location
    Xq26.3; chrX:135973837-136047269 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc9a6 mouse models; 1 with human SLC9A6 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a targeted mutation display hyperactivity and susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    961
  • Tissues
    115
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060681 Ensembl Gene Model | MGI Sequence Detail 54474 C57BL/6J ±  kb
    transcript ENSMUST00000077741 Ensembl | MGI Sequence Detail 4976 Not Applicable  
    polypeptide ENSMUSP00000076922 Ensembl | MGI Sequence Detail 702 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory