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Dido1 Gene Detail
Summary
  • Symbol
    Dido1
  • Name
    death inducer-obliterator 1
  • Synonyms
    6720461J16Rik, C130092D22Rik, D130048F08Rik, Datf1, dido, DIO-1, mKIAA0333
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344352
    NCBI Gene: 23856
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180299757-180351792 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    790 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344352
 protein coding gene Chr2:180299757-180351886 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027000
 protein coding gene Chr2:187194304-187248962 (-)
A/J MGP_AJ_G0026966
 protein coding gene Chr2:179502985-179555470 (-)
AKR/J MGP_AKRJ_G0026936
 protein coding gene Chr2:184886143-184938567 (-)
BALB/cJ MGP_BALBcJ_G0026975
 protein coding gene Chr2:179965098-180017302 (-)
C3H/HeJ MGP_C3HHeJ_G0026716
 protein coding gene Chr2:185235313-185287287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027421
 protein coding gene Chr2:192595259-192650778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024786
 protein coding gene Chr2:170192625-170246185 (-)
CAST/EiJ MGP_CASTEiJ_G0026175
 protein coding gene Chr2:183477519-183531763 (-)
CBA/J MGP_CBAJ_G0026693
 protein coding gene Chr2:199606565-199658297 (-)
DBA/2J MGP_DBA2J_G0026831
 protein coding gene Chr2:178598910-178650904 (-)
FVB/NJ MGP_FVBNJ_G0026797
 protein coding gene Chr2:177213892-177266653 (-)
LP/J MGP_LPJ_G0026932
 protein coding gene Chr2:187202987-187256980 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026816
 protein coding gene Chr2:202197247-202250334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027480
 protein coding gene Chr2:184841545-184896509 (-)
PWK/PhJ MGP_PWKPhJ_G0025911
 protein coding gene Chr2:176111926-176164449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025711
 protein coding gene Chr2:181338663-181392853 (-)
WSB/EiJ MGP_WSBEiJ_G0026247
 protein coding gene Chr2:185823325-185878253 (-)



Homology
more
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIDO1, death inducer-obliterator 1
  • Synonyms
    BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8
  • Links
    NCBI Gene ID: 11083
    neXtProt AC: NX_Q9BTC0
    UniProt: Q9BTC0

  • Chr Location
    20q13.33; chr20:62877738-62937952 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dido1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 4 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    68
  • cDNA Data
    28
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038914 Ensembl Gene Model | MGI Sequence Detail 52036 C57BL/6J ±  kb
    transcript ENSMUST00000087517 Ensembl | MGI Sequence Detail 8723 Not Applicable  
    polypeptide ENSMUSP00000084794 Ensembl | MGI Sequence Detail 2256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006479 death-inducer obliterator 1
      (term hierarchy)
    • PDB
      1WEM
    • InterPro Domains
      IPR033082 Death-inducer obliterator 1, PHD finger
      IPR012921 Spen paralogue and orthologue SPOC, C-terminal
      IPR003618 Transcription elongation factor S-II, central domain
      IPR036575 Transcription elongation factor S-II, central domain superfamily
      IPR011011 Zinc finger, FYVE/PHD-type
      IPR019787 Zinc finger, PHD-finger
      IPR001965 Zinc finger, PHD-type
      IPR019786 Zinc finger, PHD-type, conserved site
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    • GlyGen
      Q8C9B9 14 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (12 sites)
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 28
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2443557, MGI:2443624, MGI:2444396
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:56257 Garcia-Domingo D, et al., DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7992-7
    • Latest
      J:328215 Gutierrez J, et al., Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing. Cell Biosci. 2022 Jun 7;12(1):84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory